caa a22 4500 386346925 CHVBK 20180307111814.0 cr unu---uuuuu 161130e198910 xx s 000 0 eng 10.1017/S0022215100110552 doi S0022215100110552 pii (NATIONALLICENCE)cambridge-10.1017/S0022215100110552 Histogenesis of salivary gland neoplasms: a postulate with prognostic implications [Elektronische Daten] In a continually renewing cell population, stem cells can be regarded as a reservoir of cells with a high capacity for self renewal that give rise to all differentiated progeny. They are the primary source for the generation and maintenance of cellular diversity and tissue homeostasis. In general, neoplasms manifest differentiation pathways similar to those found in the development and renewal of the normal tissues from which they arise. This feature serves as a basis for classification schemes of neoplasms and, as in the normal tissues, there is usually an inverse correlation between proliferative capacity and differentiation within the neoplasms. In our postulate of the histogenesis of salivary gland neoplasia, we evoke the stem cell model to account for the considerable phenotypic heterogeneity seen with these neoplasms. We further consider the neoplasms and, in particular, their myoepithelial constituencies to be manifestations of escape from normal regulatory mechanisms that determine differentiation pathways which a stem cell and its progeny can take. Clinical and basic scientific evidence are presented to support the postulate and also to point to the mitigating role that myoepithelial differentiation has in the biological course of salivary gland neoplasms. Copyright © JLO (1984) Limited 1989 Batsakis John G. Department of Pathology, The University of Texas MD, Anderson Cancer Center, Houston, Texas Regezi Joseph A. Department of Oral Pathology, University of Michigan Dental School, Ann Arbor, Michigan Luna Mario A. Department of Pathology, The University of Texas MD, Anderson Cancer Center, Houston, Texas El-Naggar Adel Department of Pathology, The University of Texas MD, Anderson Cancer Center, Houston, Texas The Journal of Laryngology & Otology Cambridge University Press 103/10(1989-10), 939-944 0022-2151 103:10<939 1989 103 JLO https://doi.org/10.1017/S0022215100110552 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0022215100110552 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Batsakis John G. Department of Pathology, The University of Texas MD, Anderson Cancer Center, Houston, Texas NATIONALLICENCE 700 1- Regezi Joseph A. Department of Oral Pathology, University of Michigan Dental School, Ann Arbor, Michigan NATIONALLICENCE 700 1- Luna Mario A. Department of Pathology, The University of Texas MD, Anderson Cancer Center, Houston, Texas NATIONALLICENCE 700 1- El-Naggar Adel Department of Pathology, The University of Texas MD, Anderson Cancer Center, Houston, Texas NATIONALLICENCE 773 0- The Journal of Laryngology & Otology Cambridge University Press 103/10(1989-10), 939-944 0022-2151 103:10<939 1989 103 JLO CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge