caa a22 4500 386347212 CHVBK 20180307111815.0 cr unu---uuuuu 161130e198912 xx s 000 0 eng 10.1017/S0022215100111326 doi S0022215100111326 pii (NATIONALLICENCE)cambridge-10.1017/S0022215100111326 DNA content and proliferative activity of myoepitheliomas [Elektronische Daten] This report adds 16 myoepitheliomas of salivary glands to the 47 already recorded in the literature. It includes, for the first time, a flow cytometric analysis of their ploidy (DNA content) and proliferative capacity (S-phase fraction). Thirteen myoepitheliomas were diploid; three were aneuploid in their DNA content. A high proliferative capacity was always associated with an abnormal DNA content. Only one diploid myoepithelioma had a high S-phase fraction. Both flow-cytometric parameters are good predictors of an aggressive biological behaviour. Recurrences, however, were all the outcome of incomplete primary removal of the myoepitheliomas. Four of the twelve (33 per cent) diploid myoepitheliomas recurred and one, with high S-phase fraction, led to the death of the patient. Two of the three (67 per cent) aneuploid myoepitheliomas recurred. Extensive loco-regional invasion by one killed the patient. The other has clinical evidence of distant metastasis. Copyright © JLO (1984) Limited 1989 El-Naggar A. Department of Pathology, The University of Texas M. D. Anderson Cancer Center at Houston Batsakis J. G. Department of Pathology, The University of Texas M. D. Anderson Cancer Center at Houston Luna M. A. Department of Pathology, The University of Texas M. D. Anderson Cancer Center at Houston Goepfert H. Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center at Houston Tortoledo M. E. Department of Pathology, The University of Texas M. D. Anderson Cancer Center at Houston The Journal of Laryngology & Otology Cambridge University Press 103/12(1989-12), 1192-1197 0022-2151 103:12<1192 1989 103 JLO https://doi.org/10.1017/S0022215100111326 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0022215100111326 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- El-Naggar A. Department of Pathology, The University of Texas M. D. Anderson Cancer Center at Houston NATIONALLICENCE 700 1- Batsakis J. G. Department of Pathology, The University of Texas M. D. Anderson Cancer Center at Houston NATIONALLICENCE 700 1- Luna M. A. Department of Pathology, The University of Texas M. D. Anderson Cancer Center at Houston NATIONALLICENCE 700 1- Goepfert H. Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center at Houston NATIONALLICENCE 700 1- Tortoledo M. E. Department of Pathology, The University of Texas M. D. Anderson Cancer Center at Houston NATIONALLICENCE 773 0- The Journal of Laryngology & Otology Cambridge University Press 103/12(1989-12), 1192-1197 0022-2151 103:12<1192 1989 103 JLO CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge