caa a22 4500 386348294 CHVBK 20180307111819.0 cr unu---uuuuu 161130e198905 xx s 000 0 eng 10.1017/S0022215100156646 doi S0022215100156646 pii (NATIONALLICENCE)cambridge-10.1017/S0022215100156646 Effects of amiloride on the endolymphatic sac [Elektronische Daten] The effect of amiloride on the murine endolymphatic sac was investigated. The amiloride caused collapse of the lateral intercellular spaces in the endolymphatic sac epithelium and a subsequent mild endolymphatic hydrops. These changes indicated a decreased absorption of endolymph in the endolymphatic sac. Amiloride is known to inhibit the transcellular fluid transport without inducing any changes in the paracellular fluid transport. It is therefore suggested that amiloride specially inhibits the fluid and ion exchange in the apical portion of the epithelial cells resulting a decrease in transcellular fluid transport across the endolymphatic sac epithelium. The transcellular fluid transport seems to be one of the main mechanisms in the endolymphatic sac fluid exchange system. Copyright © JLO (1984) Limited 1989 Takumida M. Department of Otolaryngology, Karolinska Hospital, Karolinska Institute S-104 01 Stockholm, Sweden. Bagger-Sjöbäck D. Department of Otolaryngology, Karolinska Hospital, Karolinska Institute S-104 01 Stockholm, Sweden. The Journal of Laryngology & Otology Cambridge University Press 103/5(1989-05), 466-470 0022-2151 103:5<466 1989 103 JLO https://doi.org/10.1017/S0022215100156646 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0022215100156646 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takumida M. Department of Otolaryngology, Karolinska Hospital, Karolinska Institute S-104 01 Stockholm, Sweden NATIONALLICENCE 700 1- Bagger-Sjöbäck D. Department of Otolaryngology, Karolinska Hospital, Karolinska Institute S-104 01 Stockholm, Sweden NATIONALLICENCE 773 0- The Journal of Laryngology & Otology Cambridge University Press 103/5(1989-05), 466-470 0022-2151 103:5<466 1989 103 JLO CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge