caa a22 4500 386348367 CHVBK 20180307111819.0 cr unu---uuuuu 161130e198905 xx s 000 0 eng 10.1017/S0022215100156762 doi S0022215100156762 pii (NATIONALLICENCE)cambridge-10.1017/S0022215100156762 Neuroendocrine carcinoma of the lip (Merkel Cell tumour) examined by electron microscopy and immunohistochemistry [Elektronische Daten] A definite diagnosis of neuroendocrine carcinoma of the skin is seldom made on initial histological examination; the tumour is usually reported as a poorly differentiated or anaplastic carcinoma. By applying electron microscopy and immunohistochemistry, a correct diagnosis can be made. The ultrastructural examination shows dense-core membrane-bound granules, intermediate perinuclear filaments and desmosome-like junctions. Immunohistochemistry reveals positive staining for neuron-specific enolase and keratin, the latter in a characteristic paranuclear distribution. Confronted with an unusual clinical picture or indefinite histological diagnosis, tissue specimens should be secured for the above mentioned ancillary procedures. Copyright © JLO (1984) Limited 1989 Boysen M. Departments of Otolaryngology, Institute of Pathology, University of Oslo, The National Hospital, (Rikshospitalet), N-0027, Oslo 1, Norway. Wetteland P. Departments of Pathology, Institute of Pathology, University of Oslo, The National Hospital, (Rikshospitalet), N-0027, Oslo 1, Norway. Hovig T. Laboratory for Electron Microscopy Institute of Pathology, University of Oslo, The National Hospital, (Rikshospitalet), N-0027, Oslo 1, Norway. Brandtzaeg P. Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo, The National Hospital, (Rikshospitalet), N-0027, Oslo 1, Norway. The Journal of Laryngology & Otology Cambridge University Press 103/5(1989-05), 519-523 0022-2151 103:5<519 1989 103 JLO https://doi.org/10.1017/S0022215100156762 text/html Onlinezugriff via DOI 1 other jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0022215100156762 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Boysen M. Departments of Otolaryngology, Institute of Pathology, University of Oslo, The National Hospital, (Rikshospitalet), N-0027, Oslo 1, Norway NATIONALLICENCE 700 1- Wetteland P. Departments of Pathology, Institute of Pathology, University of Oslo, The National Hospital, (Rikshospitalet), N-0027, Oslo 1, Norway NATIONALLICENCE 700 1- Hovig T. Laboratory for Electron Microscopy Institute of Pathology, University of Oslo, The National Hospital, (Rikshospitalet), N-0027, Oslo 1, Norway NATIONALLICENCE 700 1- Brandtzaeg P. Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), Institute of Pathology, University of Oslo, The National Hospital, (Rikshospitalet), N-0027, Oslo 1, Norway NATIONALLICENCE 773 0- The Journal of Laryngology & Otology Cambridge University Press 103/5(1989-05), 519-523 0022-2151 103:5<519 1989 103 JLO CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge