caa a22 4500 386352372 CHVBK 20180307111838.0 cr unu---uuuuu 161130e198908 xx s 000 0 eng 10.1017/S003329170002417X doi S003329170002417X pii (NATIONALLICENCE)cambridge-10.1017/S003329170002417X Structural brain CT changes and cognitive deficits in elderly depressives with and without reversible dementia (‘pseudodementia') [Elektronische Daten] Twenty-six elderly (> 60 yrs) patients with DSM-III major depression were compared to 13 patients with NINCDS/ADRDA probable Alzheimer's disease (AD), and to 31 screened normal controls. Subjects were matched on age and sex. Fifteen of the 26 depressed patients were cognitively impaired on the Mini-Mental State Examination (MMSE) upon admission, but after treatment returned to the normal range. These 15 patients were defined as having the dementia syndrome of depression (DOD). The remaining 11 depressed patients were termed depressed, cognitively normal (DCN). All subjects received standardized cranial CT scans for assessment of ventricular brain ratio (VBR) and CT attenuation numbers. Subjects also received neuropsychological evaluation. CT values for the 26 depressed patients lay between those of AD patients and normal controls. CT values for the DOD subgroup clustered near those of AD patients. Patterns of cognitive deficits and correlations of CT attenuation values with cognitive measures were also similar in AD and DOD. Most patients were reassessed at a mean of two years after initial testing; of the 11 of the 15 DOD re-examined, only one had undergone cognitive decline. By contrast, all AD patients retested had declined significantly. Episodes of DOD and DCN tended to ‘breed true'. This study suggests that while patients with DOD may have underlying structural brain abnormalities, obvious short-term progression to AD does not commonly occur. Copyright © Cambridge University Press 1989 Pearlson Godfrey D. Department of Psychiatry and Behavioral Sciences, Division of Neuroradiology, Division of Medical Psychology and Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA Rabins Peter V. Department of Psychiatry and Behavioral Sciences, Division of Neuroradiology, Division of Medical Psychology and Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA Kim Won S. Department of Psychiatry and Behavioral Sciences, Division of Neuroradiology, Division of Medical Psychology and Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA Speedie Lynn J. Department of Psychiatry and Behavioral Sciences, Division of Neuroradiology, Division of Medical Psychology and Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA Moberg Paul J. Department of Psychiatry and Behavioral Sciences, Division of Neuroradiology, Division of Medical Psychology and Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA Burns Alistair Department of Psychiatry and Behavioral Sciences, Division of Neuroradiology, Division of Medical Psychology and Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA Bascom Mary J. Department of Psychiatry and Behavioral Sciences, Division of Neuroradiology, Division of Medical Psychology and Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA Psychological Medicine Cambridge University Press 19/3(1989-08), 573-584 0033-2917 19:3<573 1989 19 PSM https://doi.org/10.1017/S003329170002417X text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S003329170002417X text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pearlson Godfrey D. Department of Psychiatry and Behavioral Sciences, Division of Neuroradiology, Division of Medical Psychology and Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA NATIONALLICENCE 700 1- Rabins Peter V. Department of Psychiatry and Behavioral Sciences, Division of Neuroradiology, Division of Medical Psychology and Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA NATIONALLICENCE 700 1- Kim Won S. Department of Psychiatry and Behavioral Sciences, Division of Neuroradiology, Division of Medical Psychology and Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA NATIONALLICENCE 700 1- Speedie Lynn J. Department of Psychiatry and Behavioral Sciences, Division of Neuroradiology, Division of Medical Psychology and Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA NATIONALLICENCE 700 1- Moberg Paul J. Department of Psychiatry and Behavioral Sciences, Division of Neuroradiology, Division of Medical Psychology and Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA NATIONALLICENCE 700 1- Burns Alistair Department of Psychiatry and Behavioral Sciences, Division of Neuroradiology, Division of Medical Psychology and Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA NATIONALLICENCE 700 1- Bascom Mary J. Department of Psychiatry and Behavioral Sciences, Division of Neuroradiology, Division of Medical Psychology and Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA NATIONALLICENCE 773 0- Psychological Medicine Cambridge University Press 19/3(1989-08), 573-584 0033-2917 19:3<573 1989 19 PSM CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge