caa a22 4500 386352828 CHVBK 20180307111839.0 cr unu---uuuuu 161130e198911 xx s 000 0 eng 10.1017/S0033291700005560 doi S0033291700005560 pii (NATIONALLICENCE)cambridge-10.1017/S0033291700005560 The pattern of function-related regional cerebral blood flow investigated by single photon emission tomography with 99mTc-HMPAO in patients with presenile Alzheimer's disease and Korsakoff's psychosis [Elektronische Daten] Single photon emission tomography (SPET) with the lipophilic blood flow marker 99mTc-hexamethyl propyleneamine oxime (99mTc-HMPAO) has been used to determine regional uptake of radiolabel into brain regions of patients with presenile Alzheimer's disease and Korsakoff's psychosis, and age-matched controls. Using occipital cortical uptake as reference area, the pattern of relative regional cerebral blood flow (rCBF) was determined in other cortical areas and basal ganglia. In Alzheimer's disease, reduction in rCBF occurred most strikingly in posterior temporal and parietal areas. By contrast, in Korsakoff's psychosis, posterior temporal rCBF was maintained, although there was a trend to reduced tracer uptake in other cortical areas. These impairments of flow were correlated with impairments of neuropsychological function. In Alzheimer's disease, left posterior temporal and left parietal regions in particular showed rCBF to be strongly correlated with most aspects of cognitive function. In Korsakoff's psychosis, however, impaired flow in frontal regions was correlated with impaired performance on tests of memory and orientation. The findings in Alzheimer's disease show quantitative parallels with those from studies using Positron Emission Tomography (PET), and extend our understanding of the relationship between cognition and regional brain function in dementia. The findings in Korsakoff's psychosis offer the first direct evidence linking frontal lobe dysfunction with the cognitive impairment seen in the disorder. Copyright © Cambridge University Press 1989 Hunter R. MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh and the Wellcome Neuroscience Group, Institute of Neurological Sciences, Southern General Hospital, Glasgow McLuskie R. MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh and the Wellcome Neuroscience Group, Institute of Neurological Sciences, Southern General Hospital, Glasgow Wyper D. MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh and the Wellcome Neuroscience Group, Institute of Neurological Sciences, Southern General Hospital, Glasgow Patterson J. MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh and the Wellcome Neuroscience Group, Institute of Neurological Sciences, Southern General Hospital, Glasgow Christie J. E. MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh and the Wellcome Neuroscience Group, Institute of Neurological Sciences, Southern General Hospital, Glasgow Brooks D. N. MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh and the Wellcome Neuroscience Group, Institute of Neurological Sciences, Southern General Hospital, Glasgow McCulloch J. MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh and the Wellcome Neuroscience Group, Institute of Neurological Sciences, Southern General Hospital, Glasgow Fink G. MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh and the Wellcome Neuroscience Group, Institute of Neurological Sciences, Southern General Hospital, Glasgow Goodwin G. M. MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh and the Wellcome Neuroscience Group, Institute of Neurological Sciences, Southern General Hospital, Glasgow Psychological Medicine Cambridge University Press 19/4(1989-11), 847-855 0033-2917 19:4<847 1989 19 PSM https://doi.org/10.1017/S0033291700005560 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0033291700005560 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hunter R. MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh and the Wellcome Neuroscience Group, Institute of Neurological Sciences, Southern General Hospital, Glasgow NATIONALLICENCE 700 1- McLuskie R. MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh and the Wellcome Neuroscience Group, Institute of Neurological Sciences, Southern General Hospital, Glasgow NATIONALLICENCE 700 1- Wyper D. MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh and the Wellcome Neuroscience Group, Institute of Neurological Sciences, Southern General Hospital, Glasgow NATIONALLICENCE 700 1- Patterson J. MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh and the Wellcome Neuroscience Group, Institute of Neurological Sciences, Southern General Hospital, Glasgow NATIONALLICENCE 700 1- Christie J. E. MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh and the Wellcome Neuroscience Group, Institute of Neurological Sciences, Southern General Hospital, Glasgow NATIONALLICENCE 700 1- Brooks D. N. MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh and the Wellcome Neuroscience Group, Institute of Neurological Sciences, Southern General Hospital, Glasgow NATIONALLICENCE 700 1- McCulloch J. MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh and the Wellcome Neuroscience Group, Institute of Neurological Sciences, Southern General Hospital, Glasgow NATIONALLICENCE 700 1- Fink G. MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh and the Wellcome Neuroscience Group, Institute of Neurological Sciences, Southern General Hospital, Glasgow NATIONALLICENCE 700 1- Goodwin G. M. MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Edinburgh and the Wellcome Neuroscience Group, Institute of Neurological Sciences, Southern General Hospital, Glasgow NATIONALLICENCE 773 0- Psychological Medicine Cambridge University Press 19/4(1989-11), 847-855 0033-2917 19:4<847 1989 19 PSM CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge