caa a22 4500 386352852 CHVBK 20180307111840.0 cr unu---uuuuu 161130e198911 xx s 000 0 eng 10.1017/S0033291700005614 doi S0033291700005614 pii (NATIONALLICENCE)cambridge-10.1017/S0033291700005614 Cognitive impairment, clinical course and treatment history in out-patients with bipolar affective disorder: relationship to tardive dyskinesia [Elektronische Daten] Clinical, neuropsychological and psychopharmacological characteristics were investigated for their ability to distinguish individuals with and without involuntary movements (tardive dyskinesia), among a population of 40 out-patients with bipolar affective disorder and a history of exposure to neuroleptics and lithium. Impaired performance on a test of cognitive flexibility bore the primary association with both the presence and the severity of involuntary movements. The additional relationships identified emphasized further that individual vulnerability to involuntary movements appeared to be associated not with greater duration or dosage of treatment, but with features of the bipolar illness, including number and type of affective episodes, for which that treatment was prescribed. Copyright © Cambridge University Press 1989 Waddington John L. Department of Clinical Pharmacology, Royal College of Surgeons in Ireland; Depression and Manic-Depression Research Unit, St Patrick's Hospital; and Dublin Institute of Technology, Dublin, Ireland Brown Katherine Department of Clinical Pharmacology, Royal College of Surgeons in Ireland; Depression and Manic-Depression Research Unit, St Patrick's Hospital; and Dublin Institute of Technology, Dublin, Ireland O'Neill Jane Department of Clinical Pharmacology, Royal College of Surgeons in Ireland; Depression and Manic-Depression Research Unit, St Patrick's Hospital; and Dublin Institute of Technology, Dublin, Ireland McKeon Patrick Department of Clinical Pharmacology, Royal College of Surgeons in Ireland; Depression and Manic-Depression Research Unit, St Patrick's Hospital; and Dublin Institute of Technology, Dublin, Ireland Kinsella Anthony Department of Clinical Pharmacology, Royal College of Surgeons in Ireland; Depression and Manic-Depression Research Unit, St Patrick's Hospital; and Dublin Institute of Technology, Dublin, Ireland Psychological Medicine Cambridge University Press 19/4(1989-11), 897-902 0033-2917 19:4<897 1989 19 PSM https://doi.org/10.1017/S0033291700005614 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0033291700005614 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Waddington John L. Department of Clinical Pharmacology, Royal College of Surgeons in Ireland; Depression and Manic-Depression Research Unit, St Patrick's Hospital; and Dublin Institute of Technology, Dublin, Ireland NATIONALLICENCE 700 1- Brown Katherine Department of Clinical Pharmacology, Royal College of Surgeons in Ireland; Depression and Manic-Depression Research Unit, St Patrick's Hospital; and Dublin Institute of Technology, Dublin, Ireland NATIONALLICENCE 700 1- O'Neill Jane Department of Clinical Pharmacology, Royal College of Surgeons in Ireland; Depression and Manic-Depression Research Unit, St Patrick's Hospital; and Dublin Institute of Technology, Dublin, Ireland NATIONALLICENCE 700 1- McKeon Patrick Department of Clinical Pharmacology, Royal College of Surgeons in Ireland; Depression and Manic-Depression Research Unit, St Patrick's Hospital; and Dublin Institute of Technology, Dublin, Ireland NATIONALLICENCE 700 1- Kinsella Anthony Department of Clinical Pharmacology, Royal College of Surgeons in Ireland; Depression and Manic-Depression Research Unit, St Patrick's Hospital; and Dublin Institute of Technology, Dublin, Ireland NATIONALLICENCE 773 0- Psychological Medicine Cambridge University Press 19/4(1989-11), 897-902 0033-2917 19:4<897 1989 19 PSM CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge