caa a22 4500 386352933 CHVBK 20180307111840.0 cr unu---uuuuu 161130e198911 xx s 000 0 eng 10.1017/S0033291700005602 doi S0033291700005602 pii (NATIONALLICENCE)cambridge-10.1017/S0033291700005602 Psychiatric morbidity in multiple sclerosis: a clinical and MRI study [Elektronische Daten] This study reports the psychiatric morbidity in 116 patients with definite multiple sclerosis (MS). The presence of brain pathology was investigated using magnetic resonance imaging (MRI). A group of 48 physically disabled controls suffering from rheumatic or neurological conditions not involving the brain was used for comparison. Normative MRI data were obtained from a group of 40 healthy volunteers. Psychiatric morbidity was significantly higher in the MS group with nearly half of the patients scoring as cases at interview. There was no evidence to suggest that psychiatric symptoms in isolation were the first manifestation of MS in the present material. The presence of psychiatric illness at interview was significantly related to the degree of social stress as perceived by the patient. The severity of MRI abnormalities was greater in those with longer histories and greater physical disability, but did not show a significant relationship with global measures of psychiatric disability. Of the various psychiatric symptoms elation was significantly correlated with the presence of widespread MRI abnormalities, while flattening of affect, delusions and thought disorder correlated with the degree of pathology in the temporo-parietal region. Copyright © Cambridge University Press 1989 Ron M. A. National Hospital for Nervous Diseases, London Logsdail S. J. National Hospital for Nervous Diseases, London Psychological Medicine Cambridge University Press 19/4(1989-11), 887-895 0033-2917 19:4<887 1989 19 PSM https://doi.org/10.1017/S0033291700005602 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0033291700005602 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ron M. A. National Hospital for Nervous Diseases, London NATIONALLICENCE 700 1- Logsdail S. J. National Hospital for Nervous Diseases, London NATIONALLICENCE 773 0- Psychological Medicine Cambridge University Press 19/4(1989-11), 887-895 0033-2917 19:4<887 1989 19 PSM CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge