caa a22 4500 386353212 CHVBK 20180307111841.0 cr unu---uuuuu 161130e198911 xx s 000 0 eng 10.1017/S0033291700005572 doi S0033291700005572 pii (NATIONALLICENCE)cambridge-10.1017/S0033291700005572 The neuroendocrine responses and psychological effects of infusion of L-tryptophan in anorexia nervosa [Elektronische Daten] The secretion of prolactin and growth hormone (GH), together with subjective ratings of sedation and hunger, were determined in 13 in-patients with anorexia nervosa and 15 controls during the intravenous infusion of L-tryptophan (100 mg/kg). Prolactin responses were not different between groups but GH responses were markedly blunted in patients. In addition sedation responses in patients were attenuated compared with controls. Hunger ratings were reduced by the infusion in controls but were too variable to be interpreted in the patients. Plasma amino acid levels were also determined before and after infusion of L-tryptophan. Tryptophan levels were comparable in the two groups as were the levels of tyrosine, phenyl alanine, valine, leucine and iso-leucine. The results suggest that some aspects of 5-hydroxytryptamine function may be attenuated in anorexia nervosa. However, they undoubtedly contrast with the finding of enhanced hormonal responses in acute dieting and may be relevant to the interpretation of similar experiments in depressive illness. Copyright © Cambridge University Press 1989 Goodwin G. M. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh Shapiro C. M. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh Bennie J. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh Dick H. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh Carroll S. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh Fink G. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh Psychological Medicine Cambridge University Press 19/4(1989-11), 857-864 0033-2917 19:4<857 1989 19 PSM https://doi.org/10.1017/S0033291700005572 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0033291700005572 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goodwin G. M. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh NATIONALLICENCE 700 1- Shapiro C. M. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh NATIONALLICENCE 700 1- Bennie J. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh NATIONALLICENCE 700 1- Dick H. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh NATIONALLICENCE 700 1- Carroll S. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh NATIONALLICENCE 700 1- Fink G. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh NATIONALLICENCE 773 0- Psychological Medicine Cambridge University Press 19/4(1989-11), 857-864 0033-2917 19:4<857 1989 19 PSM CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge