caa a22 4500 386353492 CHVBK 20180307111842.0 cr unu---uuuuu 161130e198902 xx s 000 0 eng 10.1017/S003329170001103X doi S003329170001103X pii (NATIONALLICENCE)cambridge-10.1017/S003329170001103X Luteinizing hormone responses to luteinizing hormone releasing hormone (LHRH) in acute mania and the effects of lithium on LHRH and thyrotrophin releasing hormone tests in volunteers [Elektronische Daten] The endocrine responses to Luteinizing Hormone Releasing Hormone (LHRH) of eight drug-free males with mania were determined. Basal levels of Luteinizing Hormone (LH) and the plasma levels following injection of LHRH were elevated in patients compared with controls; Follicle Stimulating Hormone (FSH) and testosterone were not different. Elevated levels of LH have been described previously in recovered manic patients and have been suggested to be state-independent features of mania. In order to clarify the status of this finding, the effects of lithium administration upon hormone responses to LHRH in six male volunteers were also investigated, together with the effects upon Thyrotrophin Releasing Hormone (TRH) stimulation of Thyroid Stimulating Hormone (TSH) and prolactin release. Lithium increased the basal levels of LH and levels after injection of LHRH without effect upon FSH and testosterone. Lithium also increased basal and TRH stimulated release of TSH and basal prolactin levels. Lithium was without effect upon prolactin responses to TRH. The results are discussed in relation to current information on the mechanism of lithium's action. The implications for neuroendocrine work on recovered patients taking lithium are also explored. Copyright © Cambridge University Press 1989 Hunter R. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh Christie J. E. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh Whalley L. J. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh Bennie J. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh Carroll S. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh Dick H. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh Goodwin G. M. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh Wilson H. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh Fink G. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh Psychological Medicine Cambridge University Press 19/1(1989-02), 69-77 0033-2917 19:1<69 1989 19 PSM https://doi.org/10.1017/S003329170001103X text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S003329170001103X text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hunter R. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh NATIONALLICENCE 700 1- Christie J. E. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh NATIONALLICENCE 700 1- Whalley L. J. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh NATIONALLICENCE 700 1- Bennie J. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh NATIONALLICENCE 700 1- Carroll S. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh NATIONALLICENCE 700 1- Dick H. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh NATIONALLICENCE 700 1- Goodwin G. M. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh NATIONALLICENCE 700 1- Wilson H. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh NATIONALLICENCE 700 1- Fink G. MRC Brain Metabolism Unit and University Department of Psychiatry, Royal Edinburgh Hospital, Edinburgh NATIONALLICENCE 773 0- Psychological Medicine Cambridge University Press 19/1(1989-02), 69-77 0033-2917 19:1<69 1989 19 PSM CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge