caa a22 4500 386353662 CHVBK 20180307111843.0 cr unu---uuuuu 161130e198902 xx s 000 0 eng 10.1017/S0033291700011090 doi S0033291700011090 pii (NATIONALLICENCE)cambridge-10.1017/S0033291700011090 Bipolar II illness: course and outcome over a five-year period [Elektronische Daten] A five year semi-annual follow-up of patients with non-bipolar (N = 442), bipolar II (N = 64) and bipolar I (N = 53) major depression tracked the courses of prospectively observed major depressive, hypomanic and manic syndromes. In all three groups, depression was much more likely in any given week than was hypomania or mania. However, during the majority of weeks, no full syndrome was present and none of the groups exhibited evidence of continuing psychosocial deterioration. Though all three groups exhibited similar times to recovery from index and subsequent major depressive episodes, both bipolar groups had substantially higher relapse rates and developed more episodes of major depression, hypomania and mania. The two bipolar groups, in turn, differed by the severity of manic-like syndromes and thus remained diagnostically stable; the bipolar II patients were much less likely to develop full manic syndromes or to be hospitalized during follow-up. In conjunction with family study data showing that bipolar II disorder breeds true, these data support the separation of bipolar I and bipolar II affective disorder. Copyright © Cambridge University Press 1989 Coryell William National Institute of Mental Health Collaborative Program on the Psychobiology of Depression-Clinical Studies, University of Iowa, USA Keller Martin National Institute of Mental Health Collaborative Program on the Psychobiology of Depression-Clinical Studies, University of Iowa, USA Endicott Jean National Institute of Mental Health Collaborative Program on the Psychobiology of Depression-Clinical Studies, University of Iowa, USA Andreasen Nancy National Institute of Mental Health Collaborative Program on the Psychobiology of Depression-Clinical Studies, University of Iowa, USA Clayton Paula National Institute of Mental Health Collaborative Program on the Psychobiology of Depression-Clinical Studies, University of Iowa, USA Hirschfeld Robert National Institute of Mental Health Collaborative Program on the Psychobiology of Depression-Clinical Studies, University of Iowa, USA Psychological Medicine Cambridge University Press 19/1(1989-02), 129-141 0033-2917 19:1<129 1989 19 PSM https://doi.org/10.1017/S0033291700011090 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0033291700011090 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Coryell William National Institute of Mental Health Collaborative Program on the Psychobiology of Depression-Clinical Studies, University of Iowa, USA NATIONALLICENCE 700 1- Keller Martin National Institute of Mental Health Collaborative Program on the Psychobiology of Depression-Clinical Studies, University of Iowa, USA NATIONALLICENCE 700 1- Endicott Jean National Institute of Mental Health Collaborative Program on the Psychobiology of Depression-Clinical Studies, University of Iowa, USA NATIONALLICENCE 700 1- Andreasen Nancy National Institute of Mental Health Collaborative Program on the Psychobiology of Depression-Clinical Studies, University of Iowa, USA NATIONALLICENCE 700 1- Clayton Paula National Institute of Mental Health Collaborative Program on the Psychobiology of Depression-Clinical Studies, University of Iowa, USA NATIONALLICENCE 700 1- Hirschfeld Robert National Institute of Mental Health Collaborative Program on the Psychobiology of Depression-Clinical Studies, University of Iowa, USA NATIONALLICENCE 773 0- Psychological Medicine Cambridge University Press 19/1(1989-02), 129-141 0033-2917 19:1<129 1989 19 PSM CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge