caa a22 4500 386354138 CHVBK 20180307111844.0 cr unu---uuuuu 161130e198902 xx s 000 0 eng 10.1017/S0033291700011041 doi S0033291700011041 pii (NATIONALLICENCE)cambridge-10.1017/S0033291700011041 Platelet monoamine oxidase activity and life stress as predictors of psychopathology and coping in a community sample [Elektronische Daten] The present study, using a diathesis-stress model, attempted to confirm prior findings with platelet monoamine oxidase (MAO) activity and stress in a middle-aged, non-clinic population. One hundred and seventy-eight adult males from a statewide community club were tested for platelet MAO activity and stressful life events and were also given a variety of psychological measures of both psychopathology and psychosocial coping. The data were examined both for correlations across the total sample and for a comparison of high-risk groups (top and bottom 15% of MAO activity) with a middle MAO group. Low platelet MAO activity was related to a higher incidence of contact with mental health professionals, and more frequent use of alcohol and cigarette smoking. High MAO activity was related to higher levels of anxiety and somatization. High levels of stress were related to increased psychosocial problems reported for female and family members, higher scores on two schizophrenia-related MMPI scales (schizophrenia and paranoia subscales), but fewer idiosyncratic associations, elevated hypomanic, depression, and anxiety scores, increased alcohol use, and increased use of prescribed antianxiety and sedative medication. Neither MAO nor stress were related to current levels of psychosocial coping. Moreover, no interaction effects were uncovered for MAO activity and stress combined. Copyright © Cambridge University Press 1989 Irving Joanne Boyd Department of Psychology, University of Maryland and the Clinical Neuropharmacology Branch, NIMH, USA Coursey Robert D. Department of Psychology, University of Maryland and the Clinical Neuropharmacology Branch, NIMH, USA Buchsbaum Monte S. Department of Psychology, University of Maryland and the Clinical Neuropharmacology Branch, NIMH, USA Murphy Dennis L. Department of Psychology, University of Maryland and the Clinical Neuropharmacology Branch, NIMH, USA Psychological Medicine Cambridge University Press 19/1(1989-02), 79-90 0033-2917 19:1<79 1989 19 PSM https://doi.org/10.1017/S0033291700011041 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0033291700011041 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Irving Joanne Boyd Department of Psychology, University of Maryland and the Clinical Neuropharmacology Branch, NIMH, USA NATIONALLICENCE 700 1- Coursey Robert D. Department of Psychology, University of Maryland and the Clinical Neuropharmacology Branch, NIMH, USA NATIONALLICENCE 700 1- Buchsbaum Monte S. Department of Psychology, University of Maryland and the Clinical Neuropharmacology Branch, NIMH, USA NATIONALLICENCE 700 1- Murphy Dennis L. Department of Psychology, University of Maryland and the Clinical Neuropharmacology Branch, NIMH, USA NATIONALLICENCE 773 0- Psychological Medicine Cambridge University Press 19/1(1989-02), 79-90 0033-2917 19:1<79 1989 19 PSM CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge