caa a22 4500 386354413 CHVBK 20180307111846.0 cr unu---uuuuu 161130e198905 xx s 000 0 eng 10.1017/S0033291700012368 doi S0033291700012368 pii (NATIONALLICENCE)cambridge-10.1017/S0033291700012368 A re-investigation of the behavioural effects of intracerebral injection in marmosets of cytopathic cerebrospinal fluid from patients with schizophrenia or neurological disease [Elektronische Daten] In experiments designed to investigate transmission, cerebrospinal fluid (CSF) from patients with schizophrenia or neurological disease (Huntington's disease) which had been found to induce a cytopathic effect (CPE) in human embryonic fibroblast cell culture was injected intracerebrally into common marmosets. Behavioural observations were made on the animals during a period of 2½ years prior to injection and for 2½ years after injection. In an earlier study (Baker et al. 1983 b) we found that animals injected with CPE + ve CSF became progressively more inactive when compared with those injected with non-cytopathic (CPE - ve) CSF from control patients. In the present study we were unable to replicate this finding. No difference in behaviour emerged between animals injected with control CSF and animals injected with CSF from schizophrenics or patients with neurological disease, nor between animals injected with CPE + ve CSF and animals injected with CPE - ve CSF. The numbers of offspring produced and surviving did not differ between the groups. We conclude that the original findings were due to factors unconnected with the nature of the injected material. Copyright © Cambridge University Press 1989 Baker H. F. Division of Psychiatry, Clinical Research Centre, Harrow and the MRC Common Cold Unit, Harvard Hospital, Salisbury Ridley R. M. Division of Psychiatry, Clinical Research Centre, Harrow and the MRC Common Cold Unit, Harvard Hospital, Salisbury Crow T. J. Division of Psychiatry, Clinical Research Centre, Harrow and the MRC Common Cold Unit, Harvard Hospital, Salisbury Tyrrell D. A. J. Division of Psychiatry, Clinical Research Centre, Harrow and the MRC Common Cold Unit, Harvard Hospital, Salisbury Psychological Medicine Cambridge University Press 19/2(1989-05), 325-329 0033-2917 19:2<325 1989 19 PSM https://doi.org/10.1017/S0033291700012368 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0033291700012368 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Baker H. F. Division of Psychiatry, Clinical Research Centre, Harrow and the MRC Common Cold Unit, Harvard Hospital, Salisbury NATIONALLICENCE 700 1- Ridley R. M. Division of Psychiatry, Clinical Research Centre, Harrow and the MRC Common Cold Unit, Harvard Hospital, Salisbury NATIONALLICENCE 700 1- Crow T. J. Division of Psychiatry, Clinical Research Centre, Harrow and the MRC Common Cold Unit, Harvard Hospital, Salisbury NATIONALLICENCE 700 1- Tyrrell D. A. J. Division of Psychiatry, Clinical Research Centre, Harrow and the MRC Common Cold Unit, Harvard Hospital, Salisbury NATIONALLICENCE 773 0- Psychological Medicine Cambridge University Press 19/2(1989-05), 325-329 0033-2917 19:2<325 1989 19 PSM CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge