caa a22 4500 386354618 CHVBK 20180307111846.0 cr unu---uuuuu 161130e198905 xx s 000 0 eng 10.1017/S003329170001237X doi S003329170001237X pii (NATIONALLICENCE)cambridge-10.1017/S003329170001237X Hypothalamo-pituitary-adrenal axis abnormalities in depression: a review and a model [Elektronische Daten] A wide range of abnormalities of the hypothalamo-pituitary-adrenal (HPA) axis has been described in depression. This paper reviews recent advances in the understanding of this system, and draws them together to construct a model for the purposes of further research and discussion. It is proposed that there are two fundamental changes which both originate in the hypothalamus: an increased secretion of corticotropin-releasing hormone, and a neurally mediated adrenal hyper-responsivity to ACTH. The resulting changes in hormone regulation would be expected to produce all the characteristic HPA axis abnormalities commonly seen in depression. The model makes several predictions which could be tested by future experiment. Copyright © Cambridge University Press 1989 Charlton Bruce G. Department of Physiological Sciences, University of Newcastle upon Tyne, and MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne Ferrier I. Nicol Department of Physiological Sciences, University of Newcastle upon Tyne, and MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne Psychological Medicine Cambridge University Press 19/2(1989-05), 331-336 0033-2917 19:2<331 1989 19 PSM https://doi.org/10.1017/S003329170001237X text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S003329170001237X text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Charlton Bruce G. Department of Physiological Sciences, University of Newcastle upon Tyne, and MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne NATIONALLICENCE 700 1- Ferrier I. Nicol Department of Physiological Sciences, University of Newcastle upon Tyne, and MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne NATIONALLICENCE 773 0- Psychological Medicine Cambridge University Press 19/2(1989-05), 331-336 0033-2917 19:2<331 1989 19 PSM CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge