caa a22 4500 386356327 CHVBK 20180307111854.0 cr unu---uuuuu 161130e198910 xx s 000 0 eng 10.1017/S0266462300008503 doi S0266462300008503 pii (NATIONALLICENCE)cambridge-10.1017/S0266462300008503 Head Injury: Variability of Course and Presence of Confounding Factors [Elektronische Daten] Review of a large data base on 76 patients who had suffered head injuries and whose metabolic changes were being studied demonstrated the variability of their neurological courses and the importance of considering confounding factors in the analysis of such a group. It was apparent that many such patients continue to change neurologically and functionally for long periods of time, and that their ultimate outcome cannot be determined for at least 1 year. The study demonstrates the inherent complexity of a group of patients with head injuries and the need to use sophisticated statistical tools and a computer to demonstrate whether apparent trends are statistically valid in light of confounding factors and variabilities. Failure to take this complexity into account seems to be a major factor in many of the ongoing controversies in research on head injuries. A possible solution to the problem of potential biases introduced by lost patients would be to develop a method to use government records to obtain current addresses for patients involved in federally funded research. Copyright © Cambridge University Press 1989 Kaufman Howard H. West Virginia University Medical School Bretaudierre Jean-Pierre Queens University, Belfast Rowlands Brian J. Queens University, Belfast Stein Debra K. The Institute for Rehabilitation and Research, Houston Bernstein David P. The Institute for Rehabilitation and Research, Houston Wagner Karen A. The Institute for Rehabilitation and Research, Houston Gildenberg Philip L. University of Texas Medical School, Houston International Journal of Technology Assessment in Health Care Cambridge University Press 5/4(1989-10), 631-638 0266-4623 5:4<631 1989 5 THC https://doi.org/10.1017/S0266462300008503 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0266462300008503 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kaufman Howard H. West Virginia University Medical School NATIONALLICENCE 700 1- Bretaudierre Jean-Pierre Queens University, Belfast NATIONALLICENCE 700 1- Rowlands Brian J. Queens University, Belfast NATIONALLICENCE 700 1- Stein Debra K. The Institute for Rehabilitation and Research, Houston NATIONALLICENCE 700 1- Bernstein David P. The Institute for Rehabilitation and Research, Houston NATIONALLICENCE 700 1- Wagner Karen A. The Institute for Rehabilitation and Research, Houston NATIONALLICENCE 700 1- Gildenberg Philip L. University of Texas Medical School, Houston NATIONALLICENCE 773 0- International Journal of Technology Assessment in Health Care Cambridge University Press 5/4(1989-10), 631-638 0266-4623 5:4<631 1989 5 THC CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge