caa a22 4500 386356386 CHVBK 20180307111854.0 cr unu---uuuuu 161130e198910 xx s 000 0 eng 10.1017/S0266462300008448 doi S0266462300008448 pii (NATIONALLICENCE)cambridge-10.1017/S0266462300008448 Selection and Evaluation of Empirical Research in Technology Assessment [Elektronische Daten] Technology assessment involves application of the scientific method to the practice of medicine. Finding all of the assessment reports in a given field is not an easy task. Proper evaluation of those assessments requires the conduct of a prospective experiment in which the sources and results are blinded when the choice is made of papers to exclude and to include, and the process should be carried in duplicate. There are several available data bases for carrying out the search, but because of problems they should be supplemented by reference to the bibliographies of pertinent published articles. Clinical trials included in meta-analyses should be graded by quality and thus facilitate sensitivity analyses. Attention must be paid to the possibility of publication bias. Finally, the advent of meta-analysis makes it desirable to begin randomized controlled trials in areas of uncertainty, even when there is no possibility that individual investigators will encounter enough patients to draw valid conclusions. Copyright © Cambridge University Press 1989 Chalmers Thomas C. Harvard School of Public Health; Boston Veterans Administration Medical Center; Mount Sinai School of Medicine Hewett Peg Harvard School of Public Health Reitman Dinah Mount Sinai School of Medicine Sacks Henry S. Mount Sinai School of Medicine International Journal of Technology Assessment in Health Care Cambridge University Press 5/4(1989-10), 521-536 0266-4623 5:4<521 1989 5 THC https://doi.org/10.1017/S0266462300008448 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0266462300008448 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chalmers Thomas C. Harvard School of Public Health; Boston Veterans Administration Medical Center; Mount Sinai School of Medicine NATIONALLICENCE 700 1- Hewett Peg Harvard School of Public Health NATIONALLICENCE 700 1- Reitman Dinah Mount Sinai School of Medicine NATIONALLICENCE 700 1- Sacks Henry S. Mount Sinai School of Medicine NATIONALLICENCE 773 0- International Journal of Technology Assessment in Health Care Cambridge University Press 5/4(1989-10), 521-536 0266-4623 5:4<521 1989 5 THC CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge