caa a22 4500 386356432 CHVBK 20180307111854.0 cr unu---uuuuu 161130e198910 xx s 000 0 eng 10.1017/S0266462300008436 doi S0266462300008436 pii (NATIONALLICENCE)cambridge-10.1017/S0266462300008436 Research Methods for Obtaining Primary Evidence [Elektronische Daten] The use of new therapeutic and diagnostic technologies has become commonplace in modern medical practice. To avoid both clinical disappointment and the waste of money, health, and lives, the introduction of these technologies will have to be based on evidence that these technologies will do more good than harm. The evidence supporting their use should be derived using research methods designed to deal with placebo effects, confounders, and biases. Some of these methods, and the rationale for their use, are discussed in this article. Although the value of evidence derived from randomized controlled trials is stressed, the importance of reviewing critically the methodological details of such trials and interpreting their results with caution is emphasized. The benefits and risks of relying on case-control and cohort studies are reviewed. Copyright © Cambridge University Press 1989 Jaeschke Roman McMaster University Sackett David L. Chedoke-McMaster Hospitals International Journal of Technology Assessment in Health Care Cambridge University Press 5/4(1989-10), 503-519 0266-4623 5:4<503 1989 5 THC https://doi.org/10.1017/S0266462300008436 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0266462300008436 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jaeschke Roman McMaster University NATIONALLICENCE 700 1- Sackett David L. Chedoke-McMaster Hospitals NATIONALLICENCE 773 0- International Journal of Technology Assessment in Health Care Cambridge University Press 5/4(1989-10), 503-519 0266-4623 5:4<503 1989 5 THC CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge