caa a22 4500 38635667X CHVBK 20180307111855.0 cr unu---uuuuu 161130e198907 xx s 000 0 eng 10.1017/S0266462300007406 doi S0266462300007406 pii (NATIONALLICENCE)cambridge-10.1017/S0266462300007406 MacRae Kenneth D. Charing Cross and Westminster Medical School Pragmatic Versus Explanatory Trials [Elektronische Daten] [Kenneth D. MacRae] This article considers the distinction between "explanatory” and "pragmatic” aims in clinical trials—the distinction between testing a biological hypothesis and providing evidence to permit a choice between alternative treatment policies. The choice of treatments to compare, the selection of patients for the trial, the study size, and how the treatment comparison should be made are among the matters discussed. In general, where explanatory and pragmatic aims conflict, the pragmatic aim will often take priority. Copyright © Cambridge University Press 1989 International Journal of Technology Assessment in Health Care Cambridge University Press 5/3(1989-07), 333-339 0266-4623 5:3<333 1989 5 THC https://doi.org/10.1017/S0266462300007406 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0266462300007406 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- MacRae Kenneth D. Charing Cross and Westminster Medical School NATIONALLICENCE 773 0- International Journal of Technology Assessment in Health Care Cambridge University Press 5/3(1989-07), 333-339 0266-4623 5:3<333 1989 5 THC CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge