caa a22 4500 386375666 CHVBK 20180307112017.0 cr unu---uuuuu 161130e198906 xx s 000 0 eng 10.1017/S1742758400003581 doi S1742758400003581 pii (NATIONALLICENCE)cambridge-10.1017/S1742758400003581 Kaaya Godwin P. The International Centre of Insect Physiology and Ecology (ICIPE), P.O. Box 30772, Nairobi, Kenya Assessment of antibiotic potentials of insect antibacterial factors [Elektronische Daten] [Godwin P. Kaaya] Immune haemolymphs from the giant silkmoth, Hyalophora cecropia and, to a lesser extent, from the tsetse, Glossina morsitans morsitans possess antibacterial activities against several species of bacteria known to be pathogenic to man, animals and poultry, as demonstrated by in vitro bacterial growth inhibition assays. Cecropia immune haemolymph possesses a broader antibacterial spectrum and was found to be active against several Gram-positive and Gram-negative pathogenic bacteria. Mice injected with pre-determined lethal doses of Enterobacter cloacae, Klebsiella pneumoniae and Corynebacterium pseudotuberculosis and then treated with single intraperitoneal or subcutaneous injections of Cecropia immune haemolymph had much lower mortality than untreated controls. A possibility of developing a broad-spectrum antibiotic modelled on insect immune factors is discussed. Copyright © ICIPE 1989 Hyalophora cecropia nationallicence antibiotic nationallicence Glossina morsitans morsitans nationallicence Enterobacter cloacae nationallicence Klebsiella pneumoniae nationallicence Corynebacterium pseudotuberculosis nationallicence immune haemolymph nationallicence Hyalophora cecropia nationallicence Antibiotique nationallicence Glossina morsitans morsitans nationallicence Enterobacter cloacae nationallicence Klebsiella pneumoniae nationallicence Corynebacterium pseudotuberculosis nationallicence haemolymphe immunisé nationallicence International Journal of Tropical Insect Science Cambridge University Press 10/3(1989-06), 341-346 1742-7584 10:3<341 1989 10 JTI https://doi.org/10.1017/S1742758400003581 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S1742758400003581 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Kaaya Godwin P. The International Centre of Insect Physiology and Ecology (ICIPE), P.O. Box 30772, Nairobi, Kenya NATIONALLICENCE 773 0- International Journal of Tropical Insect Science Cambridge University Press 10/3(1989-06), 341-346 1742-7584 10:3<341 1989 10 JTI CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge