caa a22 4500 386381151 CHVBK 20180307112042.0 cr unu---uuuuu 161130e198905 xx s 000 0 eng 10.1017/S0033583500003814 doi S0033583500003814 pii (NATIONALLICENCE)cambridge-10.1017/S0033583500003814 Antitumour drug-DNA interactions: NMR studies of echinomycin and chromomycin complexes [Elektronische Daten] The intelligent design of new families of DNA-binding antitumour agents must await an understanding at the molecular level of the structure, dynamics and energetics of drug-DNA interactions on currently available systems. Recent progress in this area has been significant and reflects the interplay between footprinting methods that identify the sequence specificity of drug binding, structural approaches that define conformational features in the crystalline and solution states, hydrogen exchange techniques that monitor transient base pair opening and calorimetric methods that partition the enthalpic and entropic contributions to the binding isotherm. Copyright © Cambridge University Press 1989 Gao Xiaolian Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032 Patel Dinshaw J. Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032 Quarterly Reviews of Biophysics Cambridge University Press 22/2(1989-05), 93-138 0033-5835 22:2<93 1989 22 QRB https://doi.org/10.1017/S0033583500003814 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0033583500003814 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gao Xiaolian Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032 NATIONALLICENCE 700 1- Patel Dinshaw J. Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032 NATIONALLICENCE 773 0- Quarterly Reviews of Biophysics Cambridge University Press 22/2(1989-05), 93-138 0033-5835 22:2<93 1989 22 QRB CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge