caa a22 4500 386381178 CHVBK 20180307112042.0 cr unu---uuuuu 161130e198905 xx s 000 0 eng 10.1017/S0033583500003826 doi S0033583500003826 pii (NATIONALLICENCE)cambridge-10.1017/S0033583500003826 Perutz M. F. Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK Mechanisms of cooperativity and allosteric regulation in proteins [Elektronische Daten] [M. F. Perutz] AUosteric proteins control and coordinate chemical events in the living cell. When Monod conceived that idea he said that he had discovered the second secret of life. The first was the structure of DNA. The theory as published by Monod et al. (1963) was concerned chiefly with cooperativity and feedback inhibition of enzymes, such as the inhibition of threonine deaminase, the first enzyme in the pathway of the synthesis of isoleucine, by isoleucine, and its activation by valine. Two years later the theory was formalized by Monod et al. (1965). Copyright © Cambridge University Press 1989 Quarterly Reviews of Biophysics Cambridge University Press 22/2(1989-05), 139-237 0033-5835 22:2<139 1989 22 QRB https://doi.org/10.1017/S0033583500003826 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0033583500003826 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Perutz M. F. Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK NATIONALLICENCE 773 0- Quarterly Reviews of Biophysics Cambridge University Press 22/2(1989-05), 139-237 0033-5835 22:2<139 1989 22 QRB CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence SWISSBIB 263824810 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge