caa a22 4500 386387893 CHVBK 20180307112104.0 cr unu---uuuuu 161130e198909 xx s 000 0 eng 10.1017/S0022149X00009007 doi S0022149X00009007 pii (NATIONALLICENCE)cambridge-10.1017/S0022149X00009007 The role of macrophages on the expression of sex difference in the susceptibility to Brugia pahangi infection in C57BL/6 mice [Elektronische Daten] The role of macrophages or eosinophils on the expression of sex difference in the susceptibility to a primary Brugia pahangi infection in C57BL/6 mice was investigated by using a macrophage blockade technique (carbon treatment) or a histamine type 1 (H1) receptor antagonist (promethazine). Carbon treatment remarkably inhibited macrophage exudation, reduced the resistance of female mice, and completely abolished sex difference in the susceptibility to B. pahangi infection. Although promethazine treatment inhibited eosinophil exudation, it caused only a little increase (not significant) in the recovery rate of worms. These results suggest that macrophages have more important role(s) than do eosinophils on the expression of sex difference in the susceptibility to a primary B. pahangi infection in C57BL/6 mice. Copyright © Cambridge University Press 1989 Brugia pahangi nationallicence susceptibility nationallicence sex difference nationallicence macrophage nationallicence eosinophil nationallicence C57BL/6 mouse nationallicence Nakanishi Hirokuni Department of Medical Zoology, Nagasaki University School of Medicine, Sakamoto-machi, Nagasaki 852, Japan Horii Yoichiro Department of Medical Zoology, Nagasaki University School of Medicine, Sakamoto-machi, Nagasaki 852, Japan Fujita Koichiro Department of Medical Zoology, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo 113, Japan Journal of Helminthology Cambridge University Press 63/3(1989-09), 213-217 0022-149X 63:3<213 1989 63 JHL https://doi.org/10.1017/S0022149X00009007 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0022149X00009007 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nakanishi Hirokuni Department of Medical Zoology, Nagasaki University School of Medicine, Sakamoto-machi, Nagasaki 852, Japan NATIONALLICENCE 700 1- Horii Yoichiro Department of Medical Zoology, Nagasaki University School of Medicine, Sakamoto-machi, Nagasaki 852, Japan NATIONALLICENCE 700 1- Fujita Koichiro Department of Medical Zoology, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo 113, Japan NATIONALLICENCE 773 0- Journal of Helminthology Cambridge University Press 63/3(1989-09), 213-217 0022-149X 63:3<213 1989 63 JHL CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge