caa a22 4500 386388121 CHVBK 20180307112105.0 cr unu---uuuuu 161130e198912 xx s 000 0 eng 10.1017/S0022149X00009202 doi S0022149X00009202 pii (NATIONALLICENCE)cambridge-10.1017/S0022149X00009202 Dissociation of the protective immune response in the mouse to Strongyloides ratti [Elektronische Daten] The generation of protective immunity by various stages in the life-cycle of Strongyloides ratti and the phases against which resistance is directed has been examined in murine strongyloidiasis. Mice were exposed to natural, complete infections, were treated with thiabendazole (which largely resembles the natural infection), were treated with cambendazole (which restricts infection to the larval stage), or infected directly by oral transfer of adult worms. Mice that were infected with infective larvae alone did not become resistant to infective larvae or the complete infection but were resistant to adult worms implanted directly into the gut. Mice exposed to adult worms alone were resistant to natural infections and adults worms implanted directly but were not resistant to infective larvae. On the other hand, mice that had received prior natural infections showed evidence of resistance to infective larvae, adult worms, and natural, complete infections. It is concluded that there is immunological cross-reactivity between infective larvae and adult worms but that under certain circumstances the infective larvae are able to evade the host's protective immune response. Copyright © Cambridge University Press 1989 Strongyloides ratti nationallicence immune response nationallicence mouse nationallicence Grove David I. Department of Postgraduate Medical Education, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009 Northern Carolyn Department of Postgraduate Medical Education, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009 Journal of Helminthology Cambridge University Press 63/4(1989-12), 307-314 0022-149X 63:4<307 1989 63 JHL https://doi.org/10.1017/S0022149X00009202 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0022149X00009202 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Grove David I. Department of Postgraduate Medical Education, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009 NATIONALLICENCE 700 1- Northern Carolyn Department of Postgraduate Medical Education, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009 NATIONALLICENCE 773 0- Journal of Helminthology Cambridge University Press 63/4(1989-12), 307-314 0022-149X 63:4<307 1989 63 JHL CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge