caa a22 4500 386388164 CHVBK 20180307112105.0 cr unu---uuuuu 161130e198912 xx s 000 0 eng 10.1017/S0022149X00009226 doi S0022149X00009226 pii (NATIONALLICENCE)cambridge-10.1017/S0022149X00009226 Further studies on the effect of cyclosporin A on the course of Paragonimus infection in rats [Elektronische Daten] Paragonimus ohirai-infected rats were treated with cyclosporin A (CyA) at different times during the course of infection. CyA (5×80 mg/kg) affected the worm recovery, growth and maturation rates of P. ohirai with respect to control values. This tendency was most remarkable in animals treated 15 days and more after infection with CyA (groups B, +15 to +19 days; C, +25 to +29; D, +35 to +39 and E, +45 to +49). In group A (0 to +4), however, the drug did not affect markedly the growth and maturation of worms, although it significantly lowered worm recovery rates. CyA administration also affected normal migration of P. ohirai in the highly susceptible host (rat), when the drug was administered during the peritoneal and/or liver phase of infection. Thus, in this P. ohirai/rat model, CyA significantly reduced worm recovery rates, and affected the growth, maturation and migration of the worms depending on the time of administration. Copyright © Cambridge University Press 1989 Paragonimus ohirai nationallicence cyclosporin A nationallicence rat nationallicence immunosuppressants nationallicence Hashiguchi Yoshihisa Department of Parasitology, Kochi Medical School, Nankoku City, Kochi 781-51, Japan Okamura Yoshisuke Department of Parasitology, Kochi Medical School, Nankoku City, Kochi 781-51, Japan Journal of Helminthology Cambridge University Press 63/4(1989-12), 328-332 0022-149X 63:4<328 1989 63 JHL https://doi.org/10.1017/S0022149X00009226 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0022149X00009226 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hashiguchi Yoshihisa Department of Parasitology, Kochi Medical School, Nankoku City, Kochi 781-51, Japan NATIONALLICENCE 700 1- Okamura Yoshisuke Department of Parasitology, Kochi Medical School, Nankoku City, Kochi 781-51, Japan NATIONALLICENCE 773 0- Journal of Helminthology Cambridge University Press 63/4(1989-12), 328-332 0022-149X 63:4<328 1989 63 JHL CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge