caa a22 4500 386389357 CHVBK 20180307112109.0 cr unu---uuuuu 161130s1989 xx s 000 0 eng 10.1017/S0269727000010654 doi S0269727000010654 pii (NATIONALLICENCE)cambridge-10.1017/S0269727000010654 Petrakis Nicholas L. Department of Epidemiology and International Health, School of Medicine, University of California, San Francisco, CA 94143-0560, U.S.A. Oestrogens and other biochemical and cytological components in nipple aspirates of breast fluid: relationship to risk factors for breast disease [Elektronische Daten] [Nicholas L. Petrakis] The breast of the nonpregnant woman secretes, retains or reabsorbs a variety of endogenous and exogenous biochemical substances of potential physiological and clinical significance. Among these substances are steroid hormones, prolactin, growth hormones, and peptide growth factors. Because the concentrations of these hormones secreted into the breast ducts are often significantly higher than the concentrations in serum, the breast epithelium is commonly exposed to very high concentrations of steroid and other hormones which may play a role in the aetiology and pathogenesis of breast disease. This paper presents a brief review of published data on the cytological and biochemical constituents of breast fluid obtained by nipple aspiration and data on factors affecting oestradiol and oestrone concentrations in breast fluid. Concentrations of oestradiol and oestrone in nipple aspirate fluid are much higher than in serum, not correlated with serum levels, much lower in women who recently have given birth or breast-fed their infants, not related to day in menstrual cycle, and higher in women with biopsied benign breast disease compared with nulliparous women without breast disease. Further studies of the interrelationships of hormones, other biochemical constituents and the cytopathology of breast fluid may provide new insights into the pathophysiology and aetiology of breast diseases. Copyright © Royal Society of Edinburgh 1989 Peripheral Synthesis and Endogenous Oestrogens nationallicence Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 169-181 0269-7270 95<169 1989 95 PRB https://doi.org/10.1017/S0269727000010654 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0269727000010654 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Petrakis Nicholas L. Department of Epidemiology and International Health, School of Medicine, University of California, San Francisco, CA 94143-0560, U.S.A NATIONALLICENCE 773 0- Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 169-181 0269-7270 95<169 1989 95 PRB CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge