caa a22 4500 386389381 CHVBK 20180307112109.0 cr unu---uuuuu 161130s1989 xx s 000 0 eng 10.1017/S0269727000010617 doi S0269727000010617 pii (NATIONALLICENCE)cambridge-10.1017/S0269727000010617 King R. J. B. Hormone Biochemistry Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX, U.K. Oestrogen-receptors: an overview of recent advances in their structure and function [Elektronische Daten] [R. J. B. King] Recent advances in our understanding of the receptor components involved in the initial events of oestradiol action are reviewed with an emphasis on aspects of clinical relevance. Two main features of the models have evolved: (1) the domain structure of the ligand-binding unit, with distinct parts of the molecule being concerned with oestrogen-binding and interaction with DNA, and other parts of the molecule having important regulatory functions; (2) the regulatory regions (oestrogen-response elements) of oestrogen-sensitive genes which specifically interact with the receptor protein. The homologies between different proteins capable of binding ligands as diverse as oestradiol, retinoic acid and thyroid hormone point to possible interactions between such ligands. Oestrogen-response elements can recognise oestradiol receptor proteins complexed with either agonists or antagonists. Interactions with DNA may play an important rôle in determining gene expression additional to those seen at the receptor level. Copyright © Royal Society of Edinburgh 1989 Mechanisms and Markers of Oestrogen Action in the Breast nationallicence Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 133-144 0269-7270 95<133 1989 95 PRB https://doi.org/10.1017/S0269727000010617 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0269727000010617 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- King R. J. B. Hormone Biochemistry Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX, U.K NATIONALLICENCE 773 0- Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 133-144 0269-7270 95<133 1989 95 PRB CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge