caa a22 4500 386389403 CHVBK 20180307112109.0 cr unu---uuuuu 161130s1989 xx s 000 0 eng 10.1017/S0269727000010629 doi S0269727000010629 pii (NATIONALLICENCE)cambridge-10.1017/S0269727000010629 The clinical usefulness of oestrogen-receptor and other markers of hormone dependence [Elektronische Daten] There is an increasing trend to administer adjuvant therapy to patients with all stages of primary breast cancer. However, since only about half of these patients will eventually relapse, it would be useful to have a set of factors that could predict which patients are at high risk for recurrence and which patients are probably cured by local therapy alone. Using tumour specimens from our San Antonio Tumour Bank, we have confirmed the prognostic significance of axillary nodal status for predicting disease-free and overall survival. Among patients with node-positive disease, both oestrogen-receptors (ER) and progesterone-receptors (PgR) are predictive of patient outcome, but PgR is the more powerful factor. Using multivariate techniques, we have found that amplification and/or expression of the HER-2/neu oncogene provides additional prognostic information for node-positive patients. Among patients with node-negative disease, ER and tumour size comprise a powerful set of prognostic factors. But ploidy status and S-phase fraction, as measured by flow cytometry, provide additional independent information for predicting disease-free and overall survival. Using these factors, sub-groups of node-negative patients with low risk of recurrence who will probably not benefit from adjuvant systemic therapy might be identified. Copyright © Royal Society of Edinburgh 1989 Mechanisms and Markers of Oestrogen Action in the Breast nationallicence Clark Gary M. Department of Medicine/Oncology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78284-7884, U.S.A. McGuire William L. Department of Medicine/Oncology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78284-7884, U.S.A. Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 145-150 0269-7270 95<145 1989 95 PRB https://doi.org/10.1017/S0269727000010629 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0269727000010629 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Clark Gary M. Department of Medicine/Oncology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78284-7884, U.S.A NATIONALLICENCE 700 1- McGuire William L. Department of Medicine/Oncology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78284-7884, U.S.A NATIONALLICENCE 773 0- Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 145-150 0269-7270 95<145 1989 95 PRB CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge