caa a22 4500 38638942X CHVBK 20180307112109.0 cr unu---uuuuu 161130s1989 xx s 000 0 eng 10.1017/S0269727000010587 doi S0269727000010587 pii (NATIONALLICENCE)cambridge-10.1017/S0269727000010587 Growth control of normal and malignant breast epithelium [Elektronische Daten] We review information highlighting the multiple roles of both steroidal (primarily oestrogen) and polypeptide regulators of mammary epithelial cell growth, emphasising the work of our laboratory. Effects of both classes of hormones are complex and involve multiple interactions with non-tumour, host tissue. Oestrogen may induce growth regulatory polypeptide growth factors and interact with them in hormone dependent breast cancer. Progression of hormone-dependent breast cancer to hormone independence may involve multiple genetic mechanisms of oncogene activation, loss of the oestrogen receptor, or loss of hormone responsivity of other gene products. Initial carcinogenesis and progression of mammary epithelium to cancer probably also requires both proliferative stimuli (oestrogen, polypeptide growth factors) and genetic damage, leading to qualitatively different hormonal responses (hormone responsive cancer). Future therapies should be designed to block hormonal stimulation better and to interfere with necessary activated or induced components of malignant progression such as oncogenes or polypeptide growth factors receptor systems. Copyright © Royal Society of Edinburgh 1989 Mechanisms and Markers of Oestrogen Action in the Breast nationallicence Lippman Marc E. Lombardi Cancer Research Center, Georgetown University Medical Center, 3800 Reservoir Road, N.W., Washington, DC 20007, U.S.A. Dickson Robert B. Lombardi Cancer Research Center, Georgetown University Medical Center, 3800 Reservoir Road, N.W., Washington, DC 20007, U.S.A. Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 89-106 0269-7270 95<89 1989 95 PRB https://doi.org/10.1017/S0269727000010587 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0269727000010587 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lippman Marc E. Lombardi Cancer Research Center, Georgetown University Medical Center, 3800 Reservoir Road, N.W., Washington, DC 20007, U.S.A NATIONALLICENCE 700 1- Dickson Robert B. Lombardi Cancer Research Center, Georgetown University Medical Center, 3800 Reservoir Road, N.W., Washington, DC 20007, U.S.A NATIONALLICENCE 773 0- Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 89-106 0269-7270 95<89 1989 95 PRB CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge