caa a22 4500 386389519 CHVBK 20180307112109.0 cr unu---uuuuu 161130s1989 xx s 000 0 eng 10.1017/S026972700001054X doi S026972700001054X pii (NATIONALLICENCE)cambridge-10.1017/S026972700001054X Howell Anthony Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Wilmslow Road, Manchester M20 9BX, U.K. Clinical evidence for the involvement of oestrogen in the development and progression of breast cancer [Elektronische Daten] [Anthony Howell] Oestrogens may be involved in breast cancer development by at least three mechanisms, all of which involve stimulation of growth. Firstly, they may stimulate proliferation of the normal gland and possibly expand the pool of cells susceptible to carcinogens; secondly, they may expand the population of cells initiated by carcinogens by a promoting action to produce clinically detectable tumours; and thirdly, they may stimulate the growth and progression of infiltrating tumours. All of these effects are probably produced by interactions with the oestrogen receptor. There is suggestive evidence from immunocytochemical studies that promotion to the phase of carcinoma in situ in volves expansion of a receptor-positive clone of cells. After progression, there is a gradual loss of endocrine responsiveness either because of loss of the receptor protein or of receptor function. The high proportion of receptor-positive cells in early malignant lesions holds great hope for preventive strategies using anti-oestrogens for suppression of ovarian oestrogen production. Copyright © Royal Society of Edinburgh 1989 The Involvement of Oestrogen in the Development and Progression of Breast Disease nationallicence Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 49-57 0269-7270 95<49 1989 95 PRB https://doi.org/10.1017/S026972700001054X text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S026972700001054X text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Howell Anthony Department of Medical Oncology, Christie Hospital and Holt Radium Institute, Wilmslow Road, Manchester M20 9BX, U.K NATIONALLICENCE 773 0- Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 49-57 0269-7270 95<49 1989 95 PRB CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge