caa a22 4500 386389543 CHVBK 20180307112109.0 cr unu---uuuuu 161130s1989 xx s 000 0 eng 10.1017/S0269727000010563 doi S0269727000010563 pii (NATIONALLICENCE)cambridge-10.1017/S0269727000010563 Oestrogens in the initiation and promotion of breast cancer [Elektronische Daten] A wide variety of methods has been used to investigate the role of the oestrogens in the aetiology and clinical course of breast cancer. They include measurements of urinary metabolites and the concentrations of oestrogens in blood, saliva, nipple aspirates, cyst fluids, lymph and breast tissues. The function of the oestrogen-binding proteins has also been examined. There is no clear evidence that an excessive oestrogenic stimulus is a determinant of risk of breast cancer and it may be sensible to question this widely-held belief. Variation in the oestrogenic stimulus within the normal range might be responsible for the observed differences in tumour doubling times and for clonal selection. Case/control studies which do not include some measure of tumour growth rates are not an efficient way of investigating these possibilities. Endogenous androgen concentrations show such a strong correlation with the natural history of the disease that it would seem unwise to investigate the role of the oestrogens without taking the androgens into account. Geographical variation in the incidence of breast cancer is probably not due to racial differences in endocrine function. Copyright © Royal Society of Edinburgh 1989 The Involvement of Oestrogen in the Development and Progression of Breast Disease nationallicence Bulbrook R. D. Imperial Cancer Research Fund Laboratory, Department of Surgery, Western Infirmary, Glasgow G11 6NT, Scotland, U.K. Leake R. E. Department of Biochemistry, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K. George W. D. Imperial Cancer Research Fund Laboratory, Department of Surgery, Western Infirmary, Glasgow G11 6NT, Scotland, U.K. Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 67-76 0269-7270 95<67 1989 95 PRB https://doi.org/10.1017/S0269727000010563 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0269727000010563 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bulbrook R. D. Imperial Cancer Research Fund Laboratory, Department of Surgery, Western Infirmary, Glasgow G11 6NT, Scotland, U.K NATIONALLICENCE 700 1- Leake R. E. Department of Biochemistry, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K NATIONALLICENCE 700 1- George W. D. Imperial Cancer Research Fund Laboratory, Department of Surgery, Western Infirmary, Glasgow G11 6NT, Scotland, U.K NATIONALLICENCE 773 0- Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 67-76 0269-7270 95<67 1989 95 PRB CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge