caa a22 4500 386389551 CHVBK 20180307112109.0 cr unu---uuuuu 161130s1989 xx s 000 0 eng 10.1017/S0269727000010745 doi S0269727000010745 pii (NATIONALLICENCE)cambridge-10.1017/S0269727000010745 Use of LH-RH agonists in the treatment of breast disease [Elektronische Daten] The effects of LH-RH agonists in advanced breast cancer patients are reviewed and compared to the efficacy of surgical ablation of the ovaries and X-ray induced menopause in the treatment of this disease. In both pre- and postmenopausal women, LH-RH agonists produce pituitary gland desensitisation and a fall in concentrations of LH and FSH. In premenopausal patients plasma progesterone and oestradiol levels fall to the castrate or postmenopausal range within three to four weeks. Tumour remissions have been observed in approximately 30% of premenopausal women (50% ER-positive) and approximately 10% of postmenopausal patients. The mechanism of action of LH-RH agonists is discussed and their current application to combined endocrine therapy, early breast cancer and mastalgia briefly outlined. Copyright © Royal Society of Edinburgh 1989 Oestrogen Deprivation - Novel Methods nationallicence Nicholson R. I. Tenovus Institute for Cancer Research, University of Wales College of Medicine, Heath Park, Cardiff, CF4 4XX, U.K. Walker K. J. Tenovus Institute for Cancer Research, University of Wales College of Medicine, Heath Park, Cardiff, CF4 4XX, U.K. Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 271-281 0269-7270 95<271 1989 95 PRB https://doi.org/10.1017/S0269727000010745 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0269727000010745 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nicholson R. I. Tenovus Institute for Cancer Research, University of Wales College of Medicine, Heath Park, Cardiff, CF4 4XX, U.K NATIONALLICENCE 700 1- Walker K. J. Tenovus Institute for Cancer Research, University of Wales College of Medicine, Heath Park, Cardiff, CF4 4XX, U.K NATIONALLICENCE 773 0- Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 271-281 0269-7270 95<271 1989 95 PRB CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge