caa a22 4500 38638956X CHVBK 20180307112109.0 cr unu---uuuuu 161130s1989 xx s 000 0 eng 10.1017/S0269727000010551 doi S0269727000010551 pii (NATIONALLICENCE)cambridge-10.1017/S0269727000010551 Immunohistochemical expression of oestrogen receptor in normal breast tissue [Elektronische Daten] The human breast undergoes profound changes during the menstrual cycle. The development of monocloiial antibodies to oestrogen-receptors (ER) allows study of receptor content and distribution in individual components of breast tissue. Forty-one specimens from premenopausal patients who underwent bilateral mastectomy for benign conditions were evaluated. The patients were categorised into early follicular, late follicular, early luteal, late luteal, and menstrual phases. An HSCORE, a semiquantitative evaluation of the intensity and distribution of receptor antigen localisation, was evaluated for the ductal and lobular epithelia as a tissue mean HSCORE. ER localised to the nuclei of the epithelium and was not observed in stromal elements. Receptor concentration was greater for ER in the follicular phase but this finding was not as striking as differences between lobules in a single breast and even between breasts. This heterogeneous expression between lobules was in contrast to the relatively uniform expression of receptor within a lobule of a given specimen. Copyright © Royal Society of Edinburgh 1989 The Involvement of Oestrogen in the Development and Progression of Breast Disease nationallicence Carpenter Sarah Department of Pathology and Medicine, Duke University Medical Center, Box 3712, Durham, NC 27710, U.S.A. Georgiade Gregory Department of Plastic Surgery, Duke University Medical Center, Durham, NC 27710, U.S.A. McCarty Kenneth S. Department of Biochemistry, Box 3711, Duke University Medical Center, Durham, NC 27110, U.S.A. McCarty Kenneth S. Department of Pathology and Medicine, Duke University Medical Center, Box 3712, Durham, NC 27710, U.S.A. Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 59-66 0269-7270 95<59 1989 95 PRB https://doi.org/10.1017/S0269727000010551 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0269727000010551 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Carpenter Sarah Department of Pathology and Medicine, Duke University Medical Center, Box 3712, Durham, NC 27710, U.S.A NATIONALLICENCE 700 1- Georgiade Gregory Department of Plastic Surgery, Duke University Medical Center, Durham, NC 27710, U.S.A NATIONALLICENCE 700 1- McCarty Kenneth S. Department of Biochemistry, Box 3711, Duke University Medical Center, Durham, NC 27110, U.S.A NATIONALLICENCE 700 1- McCarty Kenneth S. Department of Pathology and Medicine, Duke University Medical Center, Box 3712, Durham, NC 27710, U.S.A NATIONALLICENCE 773 0- Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 59-66 0269-7270 95<59 1989 95 PRB CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge