caa a22 4500 386389616 CHVBK 20180307112110.0 cr unu---uuuuu 161130s1989 xx s 000 0 eng 10.1017/S026972700001068X doi S026972700001068X pii (NATIONALLICENCE)cambridge-10.1017/S026972700001068X The relevance of local oestrogen metabolism within the breast [Elektronische Daten] Ovarian oestrogens appear to have a central role in the development of the breast. However, peripheral tissues including the breast and its tumours have the potential to synthesise and metabolise oestrogens. When ovarian secretion of hormones is low, for example, after the menopause, such extra-gonadal steroidogenesis may assume biological significance. While no individual steroid conversion in the breast has been shown to correlate with levels of endogenous oestrogens, certain positive associations have been observed between enzyme activities and the presence, stage and hormone dependence of breast cancer. Thus biosynthesis of oestrogen (aromatisation) in breast fat is significantly higher in patients with breast cancer as compared to that from women with benign breast disease. Within the breasts of women with cancer, oestrogen biosynthesis is enhanced in quadrants bearing tumour. In contrast, levels of 17β-hydroxysteroid dehydrogenase are not associated with the presence of malignancy, but in women with breast cancer, activity is significantly higher in breast fat of patients with large tumours and those with nodal metastasis. There is also evidence that oestrogen sulphurylation in breast cancer is associated with hormone dependence and among postmenopausal patients with oestrogen-receptor-positive tumours, response to the aromatase inhibitor, aminoglutethimide, is restricted to cancers possessing aromatase activity. Copyright © Royal Society of Edinburgh 1989 Local Oestrogen Metabolism nationallicence Miller W. R. Department of Surgery, University of Edinburgh, Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW, Scotland, U.K. O'Neill J. S. Department of Surgery, University of Edinburgh, Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW, Scotland, U.K. Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 203-217 0269-7270 95<203 1989 95 PRB https://doi.org/10.1017/S026972700001068X text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S026972700001068X text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Miller W. R. Department of Surgery, University of Edinburgh, Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW, Scotland, U.K NATIONALLICENCE 700 1- O'Neill J. S. Department of Surgery, University of Edinburgh, Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW, Scotland, U.K NATIONALLICENCE 773 0- Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 203-217 0269-7270 95<203 1989 95 PRB CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge