caa a22 4500 386389624 CHVBK 20180307112110.0 cr unu---uuuuu 161130s1989 xx s 000 0 eng 10.1017/S0269727000010721 doi S0269727000010721 pii (NATIONALLICENCE)cambridge-10.1017/S0269727000010721 Novel antioestrogens [Elektronische Daten] Recently described 7α-alkylamide analogues of oestradiol, exemplified by ICI 164,384, have the pharmacological characteristics of pure antioestrogens. ICI 164,384 is completely free of oestrogenic activity in rodents and blocks the trophic actions of exogenous and endogenous oestradiol and of partial agonist antiooestrogens like tamoxifen. In addition, ICI 164,384 is peripherally selective, producing complete involution of the uterus without affecting LH secretion in intact female rats. In MCF-7 oestrogen-responsive, human breast cancer cells ICI 164,384 is a more potent and effective inhibitor of cell growth than tamoxifen. This difference in efficacy is reflected by a greater reduction in the proportion of cells continuing DNA synthesis in ICI 164,384-treated cultures than in tamoxifen-treated cells. This observation implies that a pure antioestrogen may provide more effective therapy of breast cancer but this will have to be demonstrated in clinical studies. Copyright © Royal Society of Edinburgh 1989 Oestrogen Deprivation - Antioestrogens nationallicence Wakeling A. E. Research Department I, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, U.K. Bowler J. Research Department I, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, U.K. Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 247-252 0269-7270 95<247 1989 95 PRB https://doi.org/10.1017/S0269727000010721 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0269727000010721 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wakeling A. E. Research Department I, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, U.K NATIONALLICENCE 700 1- Bowler J. Research Department I, ICI Pharmaceuticals, Alderley Park, Macclesfield, Cheshire, SK10 4TG, U.K NATIONALLICENCE 773 0- Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 247-252 0269-7270 95<247 1989 95 PRB CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge