caa a22 4500 386389632 CHVBK 20180307112110.0 cr unu---uuuuu 161130s1989 xx s 000 0 eng 10.1017/S0269727000010538 doi S0269727000010538 pii (NATIONALLICENCE)cambridge-10.1017/S0269727000010538 Vessey M. P. Department of Community Medicine & General Practice, Radcliffe Infirmary, Oxford, OX2 6HE, U.K. The involvement of oestrogen in the development and progression of breast disease: epidemiological evidence [Elektronische Daten] [M. P. Vessey] The epidemiological approach to the investigation of breast cancer is briefly described with special reference to case-control and cohort studies. Risk factors for breast cancer are then reviewed, paying particular attention to menstrual and reproductive factors and to body weight. Some of the hypotheses which attempt to draw the epidemiological observations together are also outlined. The effects of exposure to exogenous oestrogens are considered in more detail. There is evidence from one study that the administration of large doses of stilboestrol during pregnancy increases breast cancer risk after a latent interval of about twenty years. Conjugated equine oestrogens administered to postmenopausal women may also slightly increase breast cancer risk after prolonged use. Little information is available about the effects of any other type of "hormone replacement therapy”. Combined oral contraceptives do not appear to have any general effect on breast cancer risk, but prolonged early use, especially use before first term pregnancy, may be harmful to the breast. Copyright © Royal Society of Edinburgh 1989 The Involvement of Oestrogen in the Development and Progression of Breast Disease nationallicence Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 35-48 0269-7270 95<35 1989 95 PRB https://doi.org/10.1017/S0269727000010538 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0269727000010538 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Vessey M. P. Department of Community Medicine & General Practice, Radcliffe Infirmary, Oxford, OX2 6HE, U.K NATIONALLICENCE 773 0- Proceedings of the Royal Society of Edinburgh. Section B. Biological Sciences Royal Society of Edinburgh Scotland Foundation 95(1989), 35-48 0269-7270 95<35 1989 95 PRB CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge