caa a22 4500 386392609 CHVBK 20180307112124.0 cr unu---uuuuu 161130e198912 xx s 000 0 eng 10.1017/S0016672300028688 doi S0016672300028688 pii (NATIONALLICENCE)cambridge-10.1017/S0016672300028688 Silver Lee M. Department of Biology, Princeton University, Princeton, NJ 08544-1014 Gene dosage effects on transmission ratio distortion and fertility in mice that carry t haplotypes [Elektronische Daten] [Lee M. Silver] Complete t haplotypes can be transmitted at distorted ratios from heterozygous +/t male mice as a consequence of t-specific alleles at a series of t complex distorter loci (Tcd-1t through Tcd-4t) and a t complex responder locus. Partial t haplotypes that lack the Tcd-2t allele cannot be transmitted at the very high ratios characteristic of complete t haplotypes. The breeding studies reported here tested the possibility that the absence of Tcd-2t could be compensated for by the presence of double doses of other Tcdt alleles. The results indicate that a double dose of Tcd-4t alone will not work, but that a double dose of both Tcd-1t and Tcd-4t can promote a very high transmission ratio in the absence of Tcd-2t. These results suggest that the extent to which transmission ratios are distorted is dependent upon the absolute level of expression of the individual Tcd genes. Further studies of genotypic effects on transmission ratio distortion, as well as fertility, lead to the suggestion of a fifth t complex distorter (Tcd-5) locus within t haplotypes. Copyright © Cambridge University Press 1989 Genetical Research Cambridge University Press 54/3(1989-12), 221-225 0016-6723 54:3<221 1989 54 GRH https://doi.org/10.1017/S0016672300028688 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0016672300028688 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Silver Lee M. Department of Biology, Princeton University, Princeton, NJ 08544-1014 NATIONALLICENCE 773 0- Genetical Research Cambridge University Press 54/3(1989-12), 221-225 0016-6723 54:3<221 1989 54 GRH CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge