caa a22 4500 386392773 CHVBK 20180307112125.0 cr unu---uuuuu 161130e198912 xx s 000 0 eng 10.1017/S0016672300028640 doi S0016672300028640 pii (NATIONALLICENCE)cambridge-10.1017/S0016672300028640 Hybrid dysgenesis-induced response to selection in Drosophila melanogaster [Elektronische Daten] In Drosophila melanogaster, the P−M and I−R systems of hybrid dysgenesis are associated with high rates of transposition of P and I elements, respectively, in the germlines of dysgenic hybrids formed by crossing females of strains without active elements to males of strains containing them. Transposition rates are not markedly accelerated in the reciprocal, nondysgenic hybrids. Previous attempts to evaluate the extent to which hybrid dysgenesis-mediated P transposition contributes to mutational variance for quantitative characters by comparing the responses to selection of P−M dysgenic and nondysgenic hybrids have given variable results. This experimental design has been extended to include an additional quantitative trait and the I−R hybrid dysgenesis system. The selection responses of lines founded from both dysgenic and nondysgenic crosses showed features that would be expected from the increase in frequency of initially rare genes with major effects on the selected traits. These results differ from those of previous experiments which showed additional selection response only in lines started from dysgenic crosses, and can be explained by the occasional occurrence of large effect transposable element-induced polygenic mutations in both dysgenic and nondysgenic selection lines. High rates of transposition in populations founded from nondysgenic crosses may account for the apparently contradictory results of the earlier selection experiments, and an explanation is proposed for its occurrence. Copyright © Cambridge University Press 1989 Pignatelli Patricia M. Institute of Animal Genetics, West Mains Road, Edinburgh EH9 3JN, Scotland Mackay Trudy F. C. Institute of Animal Genetics, West Mains Road, Edinburgh EH9 3JN, Scotland Genetical Research Cambridge University Press 54/3(1989-12), 183-195 0016-6723 54:3<183 1989 54 GRH https://doi.org/10.1017/S0016672300028640 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0016672300028640 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pignatelli Patricia M. Institute of Animal Genetics, West Mains Road, Edinburgh EH9 3JN, Scotland NATIONALLICENCE 700 1- Mackay Trudy F. C. Institute of Animal Genetics, West Mains Road, Edinburgh EH9 3JN, Scotland NATIONALLICENCE 773 0- Genetical Research Cambridge University Press 54/3(1989-12), 183-195 0016-6723 54:3<183 1989 54 GRH CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge