caa a22 4500 386393079 CHVBK 20180307112126.0 cr unu---uuuuu 161130e198908 xx s 000 0 eng 10.1017/S0016672300028342 doi S0016672300028342 pii (NATIONALLICENCE)cambridge-10.1017/S0016672300028342 Non-additive inheritance of glucose phosphate isomerase activity in mice heterozygous at the Gpi-1s structural locus [Elektronische Daten] The activity of blood glucose phosphate isomerase (GPI-1) in mice heterozygous for various alleles at the Gpi-1s structural locus (heterozygotes a/b, a/c and b/c) was significantly higher than expected, on the basis of additive inheritance, from the levels in parental homozygotes. Moreover, the GPI-1 activity was higher in a/b heterozygotes than in either parent (heterosis). Studies of heat stability with kidney homogenates revealed that the relative stabilities of GPI-1 dimers was AA > AB > BB > AC ≥ BC > CC. Differences in dimer stabilities in vivo would affect the total GPI-1 levels in heterozygotes and could account for non-additive inheritance but would be insufficient to explain heterosis for GPI-1 activity. Other possible contributing factors include unequal production or stability of monomers, or higher catalytic activity of heterodimers. Monomers could also associate non-randomly but this would not be sufficient to explain heterosis. It is clear that non-additive inheritance patterns may be produced by variants of either structural or regulatory genes. Copyright © Cambridge University Press 1989 West John D. Department of Obstetrics and Gynaecology, University of Edinburgh, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9EW Flockhart Jean H. Department of Obstetrics and Gynaecology, University of Edinburgh, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9EW Genetical Research Cambridge University Press 54/1(1989-08), 27-36 0016-6723 54:1<27 1989 54 GRH https://doi.org/10.1017/S0016672300028342 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0016672300028342 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- West John D. Department of Obstetrics and Gynaecology, University of Edinburgh, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9EW NATIONALLICENCE 700 1- Flockhart Jean H. Department of Obstetrics and Gynaecology, University of Edinburgh, Centre for Reproductive Biology, 37 Chalmers Street, Edinburgh EH3 9EW NATIONALLICENCE 773 0- Genetical Research Cambridge University Press 54/1(1989-08), 27-36 0016-6723 54:1<27 1989 54 GRH CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge