caa a22 4500 386393087 CHVBK 20180307112126.0 cr unu---uuuuu 161130e198904 xx s 000 0 eng 10.1017/S0016672300028020 doi S0016672300028020 pii (NATIONALLICENCE)cambridge-10.1017/S0016672300028020 Ohta Tomoko National Institute of Genetics, Mishima 411, Japan The mutational load of a multigene family with uniform members [Elektronische Daten] [Tomoko Ohta] The mutational load of a multigene family with uniform members was studied by computer simulations. Two models of selection, truncation and exponential fitness, were examined, by using a simple model of gene conversion. It was found that the load is much smaller than the Haldane-Muller prediction under the truncation selection, and that it becomes approximately equal to the value calculated by the formula, nv(1 − q)/(m − nq), where n is the copy number, v is the rate of detrimental mutation per gene copy, m is the truncation point in terms of the number of detrimental genes eliminated, and q is the equilibrium frequency of detrimental mutation. However the equilibrium frequency cannot be analytically obtained. For the exponential fitness model, the load is close to the Haldane-Muller value. When there is no gene conversion, the load becomes larger than the cases with conversion both for the truncation and the exponential fitness models. Thus, gene conversion or other mechanisms that are responsible for contraction-expansion of mutants on chromosomes helps eliminating deleterious mutations occurring in multigene families. Copyright © Cambridge University Press 1989 Genetical Research Cambridge University Press 53/2(1989-04), 141-145 0016-6723 53:2<141 1989 53 GRH https://doi.org/10.1017/S0016672300028020 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0016672300028020 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Ohta Tomoko National Institute of Genetics, Mishima 411, Japan NATIONALLICENCE 773 0- Genetical Research Cambridge University Press 53/2(1989-04), 141-145 0016-6723 53:2<141 1989 53 GRH CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge