caa a22 4500 386393192 CHVBK 20180307112127.0 cr unu---uuuuu 161130e198904 xx s 000 0 eng 10.1017/S0016672300027981 doi S0016672300027981 pii (NATIONALLICENCE)cambridge-10.1017/S0016672300027981 The liver/erythrocyte pyruvate kinase gene complex [Pk-1] in the mouse: structural gene mutations [Elektronische Daten] Nine enzyme activity variants of liver/erythrocyte pyruvate kinase have been found amongst laboratory and wild mice. Four of these variants have been shown by biochemical and immunological criteria to be mutations of the structural gene, Pk-1s. These four structural gene mutations, and two regulatory gene mutations, define the gene complex, [Pk-1]. One allele of the structural gene, Pk-1sl, found in the inbred strain C57BL, has an unusual phenotype and affects the expression of pyruvate kinase in the liver but not erythrocyte. A possible mechanism for this tissue-specific structural gene mutation is suggested. Copyright © Cambridge University Press 1989 Fitton Lesley A. Gene Expression Group, AFRC Institute of Animal Physiology and Genetics Research, Roslin, Midlothian EH25 9PS, U.K. Bulfield Grahame Gene Expression Group, AFRC Institute of Animal Physiology and Genetics Research, Roslin, Midlothian EH25 9PS, U.K. Genetical Research Cambridge University Press 53/2(1989-04), 105-110 0016-6723 53:2<105 1989 53 GRH https://doi.org/10.1017/S0016672300027981 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0016672300027981 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fitton Lesley A. Gene Expression Group, AFRC Institute of Animal Physiology and Genetics Research, Roslin, Midlothian EH25 9PS, U.K NATIONALLICENCE 700 1- Bulfield Grahame Gene Expression Group, AFRC Institute of Animal Physiology and Genetics Research, Roslin, Midlothian EH25 9PS, U.K NATIONALLICENCE 773 0- Genetical Research Cambridge University Press 53/2(1989-04), 105-110 0016-6723 53:2<105 1989 53 GRH CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge