caa a22 4500 386393354 CHVBK 20180307112127.0 cr unu---uuuuu 161130e198910 xx s 000 0 eng 10.1017/S0016672300028469 doi S0016672300028469 pii (NATIONALLICENCE)cambridge-10.1017/S0016672300028469 Characterization of third chromosome dominant α-methyl dopa resistant mutants (Tcr) and their interactions with l(2)amd α-methyl dopa hypersensitive alleles in Drosophila melanogaster [Elektronische Daten] In Drosophila melanogaster two alleles at the Third chromosome resistance locus (Tcr; 3-39·6) were isolated in a screen of EMS mutagenized third chromosomes for dominant resistance to dietary α-methyl dopa, α-MD, a structural analogue of DOPA. Both alleles of Tcr are recessive lethals exhibiting partial complementation. Almost half (48·3%) of the Tcr40 / Tcr45 heterozygotes die as embryos but some survive past adult eclosion. Both the embryonic lethal phenotype and the adult phenotype suggest that Tcr is involved in cuticle synthesis. Tcr mutants suppress the lethality of partially complementing alleles at the α-MD hypersensitive locus, l(2)amd. The viability of Tcr40 / Tcr45, however, is not increased by the presence of a l(2)amd allele. The possibility that the Tcr and l(2)amd mutations reveal a catecholamine metabolic pathway involved in cuticle structure is discussed. Copyright © Cambridge University Press 1989 Bishop Clifton P. Department of Biology, University of Virginia, Charlottesville, Virginia 22901, USA Sherald Allen F. Department of Biology, George Mason University, Fairfax, Virginia 22030, USA Wright Theodore R. F. Department of Biology, University of Virginia, Charlottesville, Virginia 22901, USA Genetical Research Cambridge University Press 54/2(1989-10), 93-99 0016-6723 54:2<93 1989 54 GRH https://doi.org/10.1017/S0016672300028469 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0016672300028469 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bishop Clifton P. Department of Biology, University of Virginia, Charlottesville, Virginia 22901, USA NATIONALLICENCE 700 1- Sherald Allen F. Department of Biology, George Mason University, Fairfax, Virginia 22030, USA NATIONALLICENCE 700 1- Wright Theodore R. F. Department of Biology, University of Virginia, Charlottesville, Virginia 22901, USA NATIONALLICENCE 773 0- Genetical Research Cambridge University Press 54/2(1989-10), 93-99 0016-6723 54:2<93 1989 54 GRH CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge