caa a22 4500 386393397 CHVBK 20180307112127.0 cr unu---uuuuu 161130e198910 xx s 000 0 eng 10.1017/S0016672300028524 doi S0016672300028524 pii (NATIONALLICENCE)cambridge-10.1017/S0016672300028524 Origin of rare Ha-ras alleles: relationship of VTR length to a 5′ polymorphic Xho I site [Elektronische Daten] Amongst the four common Ha-ras alleles in both controls and cancer patients, we detected the presence of a polymorphic Xho I site associated specifically with the 6·6 and 7·7 kb Bam HI fragments but absent from the 7·1 and 8·2 kb alleles, as recently reported by others. We have extended this study and report here, the consistent appearance of this Xho I site in unusual alleles close in size to the two common alleles of 6·6 and 7·7 kb, in control lymphoblastoid DNA samples in a variety of tumor DNAs. Unusual alleles grouped around the 7·1 and 8·2 kb common alleles on the other hand, did not possess the Xho I site. The consistent presence of the Xho I site polymorphism, in the unusual Ha-ras alleles surrounding the 6·6 and 7·7 kb common alleles and its absence in alleles around the 7·1 and 8·2 kb common alleles, suggests that the unusual ones are derived from the corresponding common alleles to which they are closest in size. Copyright © Cambridge University Press 1989 Baxter Glenn D. Queensland Institute of Medical Research, Herston, Brisbane 4006., Australia Hayward Nicholas K. Queensland Institute of Medical Research, Herston, Brisbane 4006., Australia Collins Russell J. Division of Immunology, Department of Pathology, Royal Brisbane Hospital, Brisbane, 4006 Lavin Martin F. Queensland Institute of Medical Research, Herston, Brisbane 4006., Australia Genetical Research Cambridge University Press 54/2(1989-10), 149-153 0016-6723 54:2<149 1989 54 GRH https://doi.org/10.1017/S0016672300028524 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0016672300028524 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Baxter Glenn D. Queensland Institute of Medical Research, Herston, Brisbane 4006., Australia NATIONALLICENCE 700 1- Hayward Nicholas K. Queensland Institute of Medical Research, Herston, Brisbane 4006., Australia NATIONALLICENCE 700 1- Collins Russell J. Division of Immunology, Department of Pathology, Royal Brisbane Hospital, Brisbane, 4006 NATIONALLICENCE 700 1- Lavin Martin F. Queensland Institute of Medical Research, Herston, Brisbane 4006., Australia NATIONALLICENCE 773 0- Genetical Research Cambridge University Press 54/2(1989-10), 149-153 0016-6723 54:2<149 1989 54 GRH CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge