caa a22 4500 386399301 CHVBK 20180307112152.0 cr unu---uuuuu 161130e198908 xx s 000 0 eng 10.1017/S0031182000060972 doi S0031182000060972 pii (NATIONALLICENCE)cambridge-10.1017/S0031182000060972 Relationship between the production of interferon-α/β and interferon-γ during acute toxoplasmosis [Elektronische Daten] Acute toxoplasmosis was induced in mice, and interferon (IFN) production in serum and by spleen cells was evaluated during the infection period. Interferon was characterized by acid-treatment and anti-IFN-α/β neutralization. In order to verify the correlation between the unusual aspects of the IFN production and the induction of immunosuppression, splenocyte mitogen responsiveness was investigated concomitantly to IFN synthesis. The activity of Toxoplasma-induced serum IFN-α/β increased gradually throughout all post-infection days, but IFN-γ was not detected in the systemic circulation at any time during the infection. It was also observed that IFN-α/β production and the capacity to produce IFN-γ by spleen cells were closely and inversely correlated. As the infection progressed, more IFN-α/β was produced, and the ability of spleen cells to produce IFN-γ decreased. The observation that Toxoplasma-infected mice were concomitantly immunosuppressed (as documented by mitogen unresponsiveness and defective IFN-γ production) in direct correlation to IFN-α/β production, suggests that such IFN-α/β production is an important factor associated with acute toxoplasmosis-induced immunosuppression. Copyright © Cambridge University Press 1989 toxoplasmosis nationallicence interferons nationallicence immunosuppression nationallicence Toxoplasma gondii nationallicence Diez B. Department of Microbiology and Immunology, Basque Country University, Apartado 699, Bilbao, Spain Galdeano A. Department of Microbiology and Immunology, Basque Country University, Apartado 699, Bilbao, Spain Nicolas R. Department of Microbiology and Immunology, Basque Country University, Apartado 699, Bilbao, Spain Cisterna R. Department of Microbiology and Immunology, Basque Country University, Apartado 699, Bilbao, Spain Parasitology Cambridge University Press 99/1(1989-08), 11-15 0031-1820 99:1<11 1989 99 PAR https://doi.org/10.1017/S0031182000060972 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0031182000060972 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Diez B. Department of Microbiology and Immunology, Basque Country University, Apartado 699, Bilbao, Spain NATIONALLICENCE 700 1- Galdeano A. Department of Microbiology and Immunology, Basque Country University, Apartado 699, Bilbao, Spain NATIONALLICENCE 700 1- Nicolas R. Department of Microbiology and Immunology, Basque Country University, Apartado 699, Bilbao, Spain NATIONALLICENCE 700 1- Cisterna R. Department of Microbiology and Immunology, Basque Country University, Apartado 699, Bilbao, Spain NATIONALLICENCE 773 0- Parasitology Cambridge University Press 99/1(1989-08), 11-15 0031-1820 99:1<11 1989 99 PAR CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence SWISSBIB 386399034 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge