caa a22 4500 386399417 CHVBK 20180307112152.0 cr unu---uuuuu 161130e198902 xx s 000 0 eng 10.1017/S0031182000059692 doi S0031182000059692 pii (NATIONALLICENCE)cambridge-10.1017/S0031182000059692 Synthesis and degradation of glycogen by Schistosoma mansoni worms in vitro [Elektronische Daten] The glycogen stores of adult Schistosoma mansoni worms could be labelled by incubation of the worms, after an initial reduction of their glycogen content, in the presence of [6-14C]glucose. Subsequent breakdown of the labelled glycogen by the parasite revealed that glycogen was degraded to lactate and carbon dioxide. The degradation of glycogen, as compared to that of glucose, resulted in slightly different ratios of these two end-products. This indicates that glycogen breakdown did not replace glucose breakdown to the same extent in all cells and that Krebs-cycle activity was not uniformly distributed throughout the cells of this parasite. Both fructose and mannose could replace glucose as an energy source and the rate of glycogen synthesis from either of these two carbohydrates was higher than from glucose. No indications for glyconeogenesis from C3-units were found. Glycogen metabolism of S. mansoni was not influenced by hormones of the mammalian host. It is regulated by the external glucose concentration and by the level of the endogenous glycogen stores. Studies on paired and unpaired worms showed that no interaction between male and female was necessary for the synthesis of glycogen by female worms. Copyright © Cambridge University Press 1989 Schistosoma mansoni nationallicence synthesis nationallicence degradation nationallicence glycogen nationallicence Tielens A. G. M. Laboratory of Veterinary Biochemistry, Utrecht University, P.O. Box 80.176, 3508 TD Utrecht, AN Celik C. Laboratory of Veterinary Biochemistry, Utrecht University, P.O. Box 80.176, 3508 TD Utrecht, AN Heuvel J. M. Van Den Laboratory of Veterinary Biochemistry, Utrecht University, P.O. Box 80.176, 3508 TD Utrecht, AN Elfring R. H. Laboratory of Veterinary Biochemistry, Utrecht University, P.O. Box 80.176, 3508 TD Utrecht, AN Bergh S. G. Van Den Laboratory of Veterinary Biochemistry, Utrecht University, P.O. Box 80.176, 3508 TD Utrecht, AN Parasitology Cambridge University Press 98/1(1989-02), 67-73 0031-1820 98:1<67 1989 98 PAR https://doi.org/10.1017/S0031182000059692 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0031182000059692 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tielens A. G. M. Laboratory of Veterinary Biochemistry, Utrecht University, P.O. Box 80.176, 3508 TD Utrecht, AN NATIONALLICENCE 700 1- Celik C. Laboratory of Veterinary Biochemistry, Utrecht University, P.O. Box 80.176, 3508 TD Utrecht, AN NATIONALLICENCE 700 1- Heuvel J. M. Van Den Laboratory of Veterinary Biochemistry, Utrecht University, P.O. Box 80.176, 3508 TD Utrecht, AN NATIONALLICENCE 700 1- Elfring R. H. Laboratory of Veterinary Biochemistry, Utrecht University, P.O. Box 80.176, 3508 TD Utrecht, AN NATIONALLICENCE 700 1- Bergh S. G. Van Den Laboratory of Veterinary Biochemistry, Utrecht University, P.O. Box 80.176, 3508 TD Utrecht, AN NATIONALLICENCE 773 0- Parasitology Cambridge University Press 98/1(1989-02), 67-73 0031-1820 98:1<67 1989 98 PAR CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge