caa a22 4500 386399573 CHVBK 20180307112153.0 cr unu---uuuuu 161130e198901 xx s 000 0 eng 10.1017/S0031182000072255 doi S0031182000072255 pii (NATIONALLICENCE)cambridge-10.1017/S0031182000072255 Schistosome vaccines: current progress and future prospects [Elektronische Daten] Vaccination against human schistosomes in laboratory hosts is now a reality. A number of different parasite molecules have been shown to confer partial protective immunity against challenge infection with Schistosoma mansoni or Schistosoma japonicum in rodent or primate hosts. These antigens are unusually diverse in their structure and stage specificity. Interestingly, although all of the vaccine molecules characterized are situated in the tegument, their exposure on the parasite surface, in most instances, is transient and/or non-essential. The properties of four of these immunogens, glutathione-S-transferase (P26,28), paramyosin (Sm97), GP38, and GP18 are discussed. Despite the identification and recombinant synthesis of several promising protective antigens, vaccination of humans against schistosomiasis remains in the realm of fantasy. At the technical level, a major problem is the failure of any of the current vaccine immunogens and immunization protocols to induce levels of resistance sufficient for significant reduction of human infection or disease. Once this important hurdle is passed, human immunization trials should be attempted as the potential beneficial impact of a vaccine against schistosomiasis remains enormous. Copyright © Cambridge University Press 1989 schistosome vaccines nationallicence human trials nationallicence vaccine immunogens nationallicence future prospects nationallicence Sher A. Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA James Stephanie L. Department of Medicine, George Washington University School of Medicine, Washington, D.C. 20037, USA Correa-Oliveira R. Centro de Pesquisas ‘Rene Rachou', Belo Horizonte, M.G., Brazil Hieny Sara Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA Pearce E. Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA Parasitology Cambridge University Press 98/S1(1989-01), S61-S68 0031-1820 98:S1<S61 1989 98 PAR https://doi.org/10.1017/S0031182000072255 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0031182000072255 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sher A. Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA NATIONALLICENCE 700 1- James Stephanie L. Department of Medicine, George Washington University School of Medicine, Washington, D.C. 20037, USA NATIONALLICENCE 700 1- Correa-Oliveira R. Centro de Pesquisas ‘Rene Rachou', Belo Horizonte, M.G., Brazil NATIONALLICENCE 700 1- Hieny Sara Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA NATIONALLICENCE 700 1- Pearce E. Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA NATIONALLICENCE 773 0- Parasitology Cambridge University Press 98/S1(1989-01), S61-S68 0031-1820 98:S1<S61 1989 98 PAR CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge