caa a22 4500 386399689 CHVBK 20180307112153.0 cr unu---uuuuu 161130e198901 xx s 000 0 eng 10.1017/S003118200008344X doi S003118200008344X pii (NATIONALLICENCE)cambridge-10.1017/S003118200008344X Fairlamb A. H. Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT Novel biochemical pathways in parasitic protozoa [Elektronische Daten] [A. H. Fairlamb] Throughout evolution, enzymes and their metabolites have been highly conserved. Parasites are no exception to this and differ most markedly by the absence of metabolic pathways that are present in the mammalian host. In general, parasites are metabolically lazy and rely on the metabolism of the host both for a supply of prefabricated components such as purines, fatty acids, sterols and amino acids and for the removal of end-products. Nonetheless, parasites are metabolically highly sophisticated in that (1) they retain the genetic capacity to induce many pathways, when needed, and (2) they have developed complex mechanisms for their survival in the host. Certain unique features of the metabolism of trypanosomes, leishmania, malaria and anaerobic protozoa will be discussed. This will include (1) glycolysis and electron transport with reference to the unique organelles: the glycosome and the hydrogenosome, (2) purine salvage, pyrimidine biosynthesis and folic acid metabolism and (3) polyamine and thiol metabolism with special reference to the role of the unique metabolite of trypanosomes and leishmanias, trypanothione. Copyright © Cambridge University Press 1989 parasitic protozoa nationallicence chemotherapy nationallicence metabolism nationallicence glycolysis nationallicence electron transport nationallicence Parasitology Cambridge University Press 99/S1(1989-01), S93-S112 0031-1820 99:S1<S93 1989 99 PAR https://doi.org/10.1017/S003118200008344X text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S003118200008344X text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Fairlamb A. H. Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT NATIONALLICENCE 773 0- Parasitology Cambridge University Press 99/S1(1989-01), S93-S112 0031-1820 99:S1<S93 1989 99 PAR CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge