caa a22 4500 386399751 CHVBK 20180307112154.0 cr unu---uuuuu 161130e198901 xx s 000 0 eng 10.1017/S0031182000083451 doi S0031182000083451 pii (NATIONALLICENCE)cambridge-10.1017/S0031182000083451 Parasite development and adaptive specialization [Elektronische Daten] The complex life-cycles of parasitic animals are a product of exploiting the process of development to generate organisms with different biological potentials within a species. Successive stages of the parasite adapt to functions such as host invasion and transmission, and to the colonization of a variety of niches, often involving different hosts, tissues or cells. Understanding the molecular basis of adaptive biology among parasities is a major challenge that lies at the heart of research in contemporary parasitology. Differences in scale at the levels of genomic complexity and cell biology exist between most parasitic protozoa and helminths, rendering a cautionary note to making generalized observations. The two principal approaches used to gain insights into adaptive specializations are to start with a biological activity and identify the molecule, or select molecules with particular properties and deduce function. Both have their part to play, with their inherent advantages and limitations, and both are illustrated with examples of studies on adaptive biology among parasitic nematodes. Copyright © Cambridge University Press 1989 development nationallicence adaptation nationallicence nematodes nationallicence Bianco A. E. Department of Pure and Applied Biology, Imperial College of Science and Technology, Prince Consort Road, London SW7 2BB Maizels R. M. Department of Pure and Applied Biology, Imperial College of Science and Technology, Prince Consort Road, London SW7 2BB Parasitology Cambridge University Press 99/S1(1989-01), S113-S123 0031-1820 99:S1<S113 1989 99 PAR https://doi.org/10.1017/S0031182000083451 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0031182000083451 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bianco A. E. Department of Pure and Applied Biology, Imperial College of Science and Technology, Prince Consort Road, London SW7 2BB NATIONALLICENCE 700 1- Maizels R. M. Department of Pure and Applied Biology, Imperial College of Science and Technology, Prince Consort Road, London SW7 2BB NATIONALLICENCE 773 0- Parasitology Cambridge University Press 99/S1(1989-01), S113-S123 0031-1820 99:S1<S113 1989 99 PAR CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge