caa a22 4500 386399948 CHVBK 20180307112154.0 cr unu---uuuuu 161130e198910 xx s 000 0 eng 10.1017/S0031182000058601 doi S0031182000058601 pii (NATIONALLICENCE)cambridge-10.1017/S0031182000058601 Susceptibility to hydrogen peroxide of Plasmodium falciparum infecting glucose-6-phosphate dehydrogenase-deficient erythrocytes [Elektronische Daten] The susceptibility to oxidant-mediated killing of Plasmodium falciparum infecting normal and glucose-6-phosphate dehydrogenase (G6PD)-deficient erythrocytes was assessed by exposure to hydrogen peroxide generated by the glucose-glucose oxidase system. The parasites infecting G6PD-deficient erythrocytes had markedly greater susceptibility to hydrogen peroxide under a variety of conditions than those infecting normal erythrocytes. In both cases, the killing effect was mediated mainly through the host cells since treatment of the erythrocytes with hydrogen peroxide did not change their relative susceptibility. The parasites were most susceptible during maturation, especially in G6PD-deficient erythrocytes, although a reduction in parasite invasion was also observed. The role of oxidant-mediated killing in the protection of G6PD-deficient hosts from P. falciparum infection is discussed. Copyright © Cambridge University Press 1989 Plasmodium falciparum nationallicence hydrogen peroxide nationallicence glucose-6-phosphate dehydrogenase nationallicence susceptibility nationallicence Kamchonwongpaisan S. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital Bunyaratvej A. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital Wanachiwanawin W. Department of Medicine, Faculty of Medicine, Siriraj Hospital Yuthavong Y. Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand Parasitology Cambridge University Press 99/2(1989-10), 171-174 0031-1820 99:2<171 1989 99 PAR https://doi.org/10.1017/S0031182000058601 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0031182000058601 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kamchonwongpaisan S. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital NATIONALLICENCE 700 1- Bunyaratvej A. Department of Pathology, Faculty of Medicine, Ramathibodi Hospital NATIONALLICENCE 700 1- Wanachiwanawin W. Department of Medicine, Faculty of Medicine, Siriraj Hospital NATIONALLICENCE 700 1- Yuthavong Y. Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand NATIONALLICENCE 773 0- Parasitology Cambridge University Press 99/2(1989-10), 171-174 0031-1820 99:2<171 1989 99 PAR CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge