caa a22 4500 386400075 CHVBK 20180307112155.0 cr unu---uuuuu 161130e198904 xx s 000 0 eng 10.1017/S0031182000062193 doi S0031182000062193 pii (NATIONALLICENCE)cambridge-10.1017/S0031182000062193 Host predisposition to trichuriasis: the mouse — T. muris model [Elektronische Daten] Predisposition to trichuriasis in mice is reflected in the inability of certain strains, or certain individuals within strains, to express protective immunity. Poor responders fail to expel worms and harbour chronic patent infections. The mechanisms underlying this phenomenon were studied in poor responder mice challenged after abbreviated or prolonged primary infections. Mice exposed to a complete primary infection were fully susceptible when challenged after the removal of the primary infection by anthelmintic. Failure to expel either infection suggests (a) that non-responsiveness to a primary infection does not reflect an inability to expel worms of a certain size, i.e. is not a consequence of the speed of the immune response in relation to parasite growth and (b) that non-responsiveness is long-lasting. Challenge after abbreviation of primary infections at different stages of worm development showed that persistence of larvae beyond day 21 was critical in determining poor response to reinfection. By inference the same conclusion can be drawn about the inability of such mice to expel primary infections. Serological analysis suggested a relationship between low antibody titres, restricted antigen recognition profiles and resistance to infection. It is suggested that the later stages of parasite development are immunosuppressive; the implications for human trichuriasis are discussed. Copyright © Cambridge University Press 1989 trichuriasis nationallicence predisposition nationallicence non-responsiveness nationallicence Trichuris muris nationallicence Else K. J. MRC Experimental Parasitology Group, Department of Zoology, University of Nottingham, University Park, Nottingham NG7 2RD Wakelin D. MRC Experimental Parasitology Group, Department of Zoology, University of Nottingham, University Park, Nottingham NG7 2RD Roach T. I. A. MRC Experimental Parasitology Group, Department of Zoology, University of Nottingham, University Park, Nottingham NG7 2RD Parasitology Cambridge University Press 98/2(1989-04), 275-282 0031-1820 98:2<275 1989 98 PAR https://doi.org/10.1017/S0031182000062193 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0031182000062193 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Else K. J. MRC Experimental Parasitology Group, Department of Zoology, University of Nottingham, University Park, Nottingham NG7 2RD NATIONALLICENCE 700 1- Wakelin D. MRC Experimental Parasitology Group, Department of Zoology, University of Nottingham, University Park, Nottingham NG7 2RD NATIONALLICENCE 700 1- Roach T. I. A. MRC Experimental Parasitology Group, Department of Zoology, University of Nottingham, University Park, Nottingham NG7 2RD NATIONALLICENCE 773 0- Parasitology Cambridge University Press 98/2(1989-04), 275-282 0031-1820 98:2<275 1989 98 PAR CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge