caa a22 4500 386400156 CHVBK 20180307112155.0 cr unu---uuuuu 161130e198904 xx s 000 0 eng 10.1017/S0031182000062119 doi S0031182000062119 pii (NATIONALLICENCE)cambridge-10.1017/S0031182000062119 Effect of Praziquantel treatment on lung-stage larvae of Schistosoma mansoni in vivo [Elektronische Daten] Mice infected heavily with Schistosoma mansoni cercariae were treated 6 days later with Praziquantel and the parasites studied 1 h post-treatment. Immunofluorescence experiments showed that parasite surface antigens became available for labelling in larvae harvested from Praziquantel-treated mice, but not from untreated mice. Red blood cell antigens acquired from the host were localized on all lung worms studied. The distribution of each set of antigens, as revealed by fluorescence-labelling was, however, quite different. The lungs of heavily infected, drug-treated mice, exhibited severe haemorrhages which occurred in a dose-dependent manner. Fewer haemorrhages were found when heavily infected mice were treated simultaneously with Praziquantel and Aprotinin, a proteinase inhibitor. These results indicate that Praziquantel treatment in vivo induces the exposure of parasite antigens on lung-stage worms and may cause the release of parasite-derived enzymes which induce haemorrhages in the lung tissue of the host. Copyright © Cambridge University Press 1989 Schistosoma mansoni nationallicence Praziquantel nationallicence immunofluorescence nationallicence proteinases nationallicence surface antigens nationallicence Flisser Ana Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA McLaren Diane J. Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA Parasitology Cambridge University Press 98/2(1989-04), 203-211 0031-1820 98:2<203 1989 98 PAR https://doi.org/10.1017/S0031182000062119 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1017/S0031182000062119 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Flisser Ana Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA NATIONALLICENCE 700 1- McLaren Diane J. Division of Parasitology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA NATIONALLICENCE 773 0- Parasitology Cambridge University Press 98/2(1989-04), 203-211 0031-1820 98:2<203 1989 98 PAR CC0 http://creativecommons.org/publicdomain/zero/1.0 nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-cambridge